Cell Senescence Entries for FASN

Cell Types
Foreskin fibroblast
Cell Lines
HFFF2
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Fafián-Labora et al. (2020) FASN activity is important for the initial stages of the induction of senescence. Cell Death Dis 10(4)318 (PubMed)

FASN Gene Information

HGNC symbol
FASN 
Aliases
FAS; SDR27X1 
Common name
fatty acid synthase 
Entrez Id
2194
Description
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008].

FASN Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:6631; fatty acid metabolic process
GO:9058; biosynthetic process
GO:6633; fatty acid biosynthetic process
GO:8152; metabolic process
GO:1649; osteoblast differentiation
GO:2068; glandular epithelial cell development
GO:6954; inflammatory response
GO:8611; ether lipid biosynthetic process
GO:9888; tissue development
GO:30223; neutrophil differentiation
GO:30224; monocyte differentiation
GO:30879; mammary gland development
GO:71353; cellular response to interleukin-4
GO:90557; establishment of endothelial intestinal barrier
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5829; cytosol
GO:5886; plasma membrane
GO:42470; melanosome
GO:70062; extracellular exosome
GO:42587; glycogen granule
Function: GO:3723; RNA binding
GO:16740; transferase activity
GO:16491; oxidoreductase activity
GO:16787; hydrolase activity
GO:16829; lyase activity
GO:16746; acyltransferase activity
GO:3824; catalytic activity
GO:5515; protein binding
GO:4312; fatty acid synthase activity
GO:4313; [acyl-carrier-protein] S-acetyltransferase activity
GO:4314; [acyl-carrier-protein] S-malonyltransferase activity
GO:4315; 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:4316; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:4317; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
GO:4320; oleoyl-[acyl-carrier-protein] hydrolase activity
GO:8659; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
GO:8693; 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
GO:16295; myristoyl-[acyl-carrier-protein] hydrolase activity
GO:16296; palmitoyl-[acyl-carrier-protein] hydrolase activity
GO:16297; acyl-[acyl-carrier-protein] hydrolase activity
GO:16418; S-acetyltransferase activity
GO:16419; S-malonyltransferase activity
GO:19171; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
GO:31177; phosphopantetheine binding
GO:47117; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
GO:47451; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO:45296; cadherin binding
Hide GO terms

Homologs of FASN in Model Organisms

Caenorhabditis elegans
fasn-1
Danio rerio
fasn
Drosophila melanogaster
v(2)k05816
Mus musculus
Fasn
Rattus norvegicus
Fasn

External links

OMIM
600212
Ensembl
ENSG00000169710
Entrez Gene
2194
UniGene
83190
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FASN
GeneCards
FASN