Cell Senescence Entries for FBXO4

Cell Types
Squamous carcinoma
Cell Lines
UM-SCC-74B
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Qie et al. (2018) Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma. Nat Commun 8(1)1534 (PubMed)

FBXO4 Gene Information

HGNC symbol
FBXO4 
Aliases
FBX4 
Common name
F-box protein 4 
Entrez Id
26272
Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].

FBXO4 Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:31146; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:32212; positive regulation of telomere maintenance via telomerase
GO:31647; regulation of protein stability
GO:31398; positive regulation of protein ubiquitination
GO:6511; ubiquitin-dependent protein catabolic process
GO:723; telomere maintenance
GO:7568; aging
GO:10608; posttranscriptional regulation of gene expression
GO:19725; cellular homeostasis
GO:31648; protein destabilization
GO:35726; common myeloid progenitor cell proliferation
GO:48147; negative regulation of fibroblast proliferation
GO:71479; cellular response to ionizing radiation
GO:1900181; negative regulation of protein localization to nucleus
GO:1902916; positive regulation of protein polyubiquitination
GO:2000001; regulation of DNA damage checkpoint
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:19005; SCF ubiquitin ligase complex
GO:151; ubiquitin ligase complex
Function: GO:5515; protein binding
GO:42803; protein homodimerization activity
GO:4842; ubiquitin-protein transferase activity
GO:61630; ubiquitin protein ligase activity
Hide GO terms

Homologs of FBXO4 in Model Organisms

Danio rerio
si:dkey-46a10.2
Mus musculus
Fbxo4
Rattus norvegicus
Fbxo4

External links

OMIM
609090
Ensembl
ENSG00000151876
Entrez Gene
26272
UniGene
165575
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FBXO4
GeneCards
FBXO4