Cell Senescence Entries for FDPS
- Cell Types
- Breast cancer
- Cell Lines
- MCF-7
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Efimova et al. (2019) HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation. Mol Cancer Ther 17(2)407-418 (PubMed)
FDPS Gene Information
- HGNC symbol
- FDPS
- Aliases
- Common name
- farnesyl diphosphate synthase
- Entrez Id
- 2224
- Description
- This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008].
FDPS Ontologies
- Gene Ontology
-
Process: GO:8299; isoprenoid biosynthetic process
GO:6629; lipid metabolic process
GO:6694; steroid biosynthetic process
GO:6695; cholesterol biosynthetic process
GO:8202; steroid metabolic process
GO:8203; cholesterol metabolic process
GO:16126; sterol biosynthetic process
GO:33384; geranyl diphosphate biosynthetic process
GO:45337; farnesyl diphosphate biosynthetic process
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
Hide GO termsFunction: GO:16740; transferase activity
GO:3723; RNA binding
GO:46872; metal ion binding
GO:5515; protein binding
GO:4161; dimethylallyltranstransferase activity
GO:4337; geranyltranstransferase activity
Homologs of FDPS in Model Organisms
- Caenorhabditis elegans
- fdps-1
- Danio rerio
- fdps
- Drosophila melanogaster
- Fpps
- Mus musculus
- Fdps
- Rattus norvegicus
- Fdps
- Saccharomyces cerevisiae
- ERG20
- Schizosaccharomyces pombe
- fps1
External links
- OMIM
- 134629
- Ensembl
- ENSG00000160752
- Entrez Gene
- 2224
- UniGene
- 335918
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- FDPS
- GeneCards
- FDPS