The FGFR2 gene and its putative association with human ageing

Cell Types

Lung fibroblast

Cell Lines

IMR-90

Cancer Cell?

No

Method

Mutation

Type of senescence

Oncogene-induced

Senescence Effect

Unclear

Primary Reference

Ota et al. (2009) The role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects. Hum Mol Genet 18(14)2609-21 (PubMed)

HGNC symbol

FGFR2

Aliases

BEK; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25

Common name

fibroblast growth factor receptor 2

Entrez Id

2263

Description

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].

Gene Ontology

Process:

GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:8284; positive regulation of cell population proliferation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:51781; positive regulation of cell division
GO:30177; positive regulation of Wnt signaling pathway
GO:60348; bone development
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:1525; angiogenesis
GO:8543; fibroblast growth factor receptor signaling pathway
GO:46777; protein autophosphorylation
GO:7267; cell-cell signaling
GO:7409; axonogenesis
GO:45165; cell fate commitment
GO:43410; positive regulation of MAPK cascade
GO:30282; bone mineralization
GO:60349; bone morphogenesis
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:30855; epithelial cell differentiation
GO:31069; hair follicle morphogenesis
GO:48562; embryonic organ morphogenesis
GO:35265; organ growth
GO:1701; in utero embryonic development
GO:22612; gland morphogenesis
GO:10839; negative regulation of keratinocyte proliferation
GO:9887; animal organ morphogenesis
GO:45787; positive regulation of cell cycle
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:33674; positive regulation of kinase activity
GO:32808; lacrimal gland development
GO:50679; positive regulation of epithelial cell proliferation
GO:2053; positive regulation of mesenchymal cell proliferation
GO:3148; outflow tract septum morphogenesis
GO:42472; inner ear morphogenesis
GO:48286; lung alveolus development
GO:48557; embryonic digestive tract morphogenesis
GO:48608; reproductive structure development
GO:30901; midbrain development
GO:1657; ureteric bud development
GO:70372; regulation of ERK1 and ERK2 cascade
GO:60484; lung-associated mesenchyme development
GO:18108; peptidyl-tyrosine phosphorylation
GO:42476; odontogenesis
GO:8589; regulation of smoothened signaling pathway
GO:48568; embryonic organ development
GO:30324; lung development
GO:48565; digestive tract development
GO:10518; positive regulation of phospholipase activity
GO:48705; skeletal system morphogenesis
GO:48762; mesenchymal cell differentiation
GO:33688; regulation of osteoblast proliferation
GO:45667; regulation of osteoblast differentiation
GO:1837; epithelial to mesenchymal transition
GO:3149; membranous septum morphogenesis
GO:3416; endochondral bone growth
GO:9791; post-embryonic development
GO:9880; embryonic pattern specification
GO:16331; morphogenesis of embryonic epithelium
GO:21769; orbitofrontal cortex development
GO:21847; ventricular zone neuroblast division
GO:21860; pyramidal neuron development
GO:30916; otic vesicle formation
GO:32496; response to lipopolysaccharide
GO:35602; fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
GO:35603; fibroblast growth factor receptor signaling pathway involved in hemopoiesis
GO:35604; fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
GO:35607; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:42060; wound healing
GO:44344; cellular response to fibroblast growth factor stimulus
GO:45471; response to ethanol
GO:48333; mesodermal cell differentiation
GO:48661; positive regulation of smooth muscle cell proliferation
GO:48701; embryonic cranial skeleton morphogenesis
GO:48730; epidermis morphogenesis
GO:48755; branching morphogenesis of a nerve
GO:50680; negative regulation of epithelial cell proliferation
GO:51150; regulation of smooth muscle cell differentiation
GO:55010; ventricular cardiac muscle tissue morphogenesis
GO:60045; positive regulation of cardiac muscle cell proliferation
GO:60174; limb bud formation
GO:60442; branching involved in prostate gland morphogenesis
GO:60445; branching involved in salivary gland morphogenesis
GO:60449; bud elongation involved in lung branching
GO:60463; lung lobe morphogenesis
GO:60501; positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:60512; prostate gland morphogenesis
GO:60523; prostate epithelial cord elongation
GO:60527; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:60529; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:60595; fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:60601; lateral sprouting from an epithelium
GO:60615; mammary gland bud formation
GO:60664; epithelial cell proliferation involved in salivary gland morphogenesis
GO:60667; branch elongation involved in salivary gland morphogenesis
GO:60670; branching involved in labyrinthine layer morphogenesis
GO:60688; regulation of morphogenesis of a branching structure
GO:60915; mesenchymal cell differentiation involved in lung development
GO:60916; mesenchymal cell proliferation involved in lung development
GO:71300; cellular response to retinoic acid
GO:71560; cellular response to transforming growth factor beta stimulus
GO:48513; animal organ development
GO:71363; cellular response to growth factor stimulus
GO:71495; cellular response to endogenous stimulus

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:5886; plasma membrane
GO:5576; extracellular region
GO:5938; cell cortex
GO:9986; cell surface
GO:5887; integral component of plasma membrane
GO:62023; collagen-containing extracellular matrix
GO:43235; receptor complex
GO:60076; excitatory synapse

Function:

GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:8201; heparin binding
GO:42802; identical protein binding
GO:5007; fibroblast growth factor-activated receptor activity
GO:17134; fibroblast growth factor binding

Hide GO terms

Danio rerio

fgfr2

Mus musculus

Fgfr2

Rattus norvegicus

Fgfr2

LongevityMap