Cell Senescence Entries for FGFR3

Cell Types
Pancreatic cancer
Cell Lines
BxPC-3, Capan-2
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Lafitte et al. (2013) FGFR3 has tumor suppressor properties in cells with epithelial phenotype. Mol Cancer 12(2)83 (PubMed)

FGFR3 Gene Information

HGNC symbol
FGFR3 
Aliases
ACH; CD333; CEK2; JTK4 
Common name
fibroblast growth factor receptor 3 
Entrez Id
2261
Description
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017].

FGFR3 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:8284; positive regulation of cell population proliferation
GO:8543; fibroblast growth factor receptor signaling pathway
GO:46777; protein autophosphorylation
GO:43410; positive regulation of MAPK cascade
GO:60349; bone morphogenesis
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:1501; skeletal system development
GO:2062; chondrocyte differentiation
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:33674; positive regulation of kinase activity
GO:1958; endochondral ossification
GO:30282; bone mineralization
GO:42531; positive regulation of tyrosine phosphorylation of STAT protein
GO:18108; peptidyl-tyrosine phosphorylation
GO:43552; positive regulation of phosphatidylinositol 3-kinase activity
GO:70977; bone maturation
GO:165; MAPK cascade
GO:10518; positive regulation of phospholipase activity
GO:3416; endochondral bone growth
GO:7267; cell-cell signaling
GO:35988; chondrocyte proliferation
GO:48640; negative regulation of developmental growth
GO:1902178; fibroblast growth factor receptor apoptotic signaling pathway
GO:48513; animal organ development
GO:71363; cellular response to growth factor stimulus
GO:71495; cellular response to endogenous stimulus
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:5783; endoplasmic reticulum
GO:5886; plasma membrane
GO:5576; extracellular region
GO:5925; focal adhesion
GO:5887; integral component of plasma membrane
GO:30133; transport vesicle
GO:43235; receptor complex
GO:5634; nucleus
GO:5737; cytoplasm
GO:9986; cell surface
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:5007; fibroblast growth factor-activated receptor activity
GO:17134; fibroblast growth factor binding
Hide GO terms

Homologs of FGFR3 in Model Organisms

Danio rerio
fgfr3
Mus musculus
Fgfr3
Rattus norvegicus
Fgfr3

External links

OMIM
134934
Ensembl
ENSG00000068078
Entrez Gene
2261
UniGene
1420
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FGFR3
GeneCards
FGFR3