Cell Senescence Entries for FIS1

Cell Types
Cervical cancer, Hepatoma
Cell Lines
ATCC, CCL-13, HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2007) Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J Biol Chem 282(31)22977-83 (PubMed)

FIS1 Gene Information

HGNC symbol
FIS1 
Aliases
CGI-135; H_NH0132A01.6; TTC11 
Common name
fission, mitochondrial 1 
Entrez Id
51024
Description
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008].

FIS1 Ontologies

Gene Ontology
Process: GO:6915; apoptotic process
GO:6626; protein targeting to mitochondrion
GO:8053; mitochondrial fusion
GO:266; mitochondrial fission
GO:90141; positive regulation of mitochondrial fission
GO:90314; positive regulation of protein targeting to membrane
GO:422; autophagy of mitochondrion
GO:1836; release of cytochrome c from mitochondria
GO:70584; mitochondrion morphogenesis
GO:10821; regulation of mitochondrion organization
GO:16559; peroxisome fission
GO:43653; mitochondrial fragmentation involved in apoptotic process
GO:2001244; positive regulation of intrinsic apoptotic signaling pathway
GO:7204; positive regulation of cytosolic calcium ion concentration
GO:43280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:35584; calcium-mediated signaling using intracellular calcium source
GO:32471; negative regulation of endoplasmic reticulum calcium ion concentration
GO:51561; positive regulation of mitochondrial calcium ion concentration
GO:1903579; negative regulation of ATP metabolic process
GO:2000192; negative regulation of fatty acid transport
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:32991; protein-containing complex
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
GO:5777; peroxisome
GO:5783; endoplasmic reticulum
GO:5778; peroxisomal membrane
GO:31307; integral component of mitochondrial outer membrane
GO:5829; cytosol
GO:5779; integral component of peroxisomal membrane
Function: GO:42802; identical protein binding
GO:5515; protein binding
Hide GO terms

Homologs of FIS1 in Model Organisms

Caenorhabditis elegans
fis-2
Danio rerio
uncharacterized_E9QG
Drosophila melanogaster
Fis1
Mus musculus
Fis1
Rattus norvegicus
Fis1
Saccharomyces cerevisiae
FIS1
Schizosaccharomyces pombe
fis1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as FIS1

External links

OMIM
609003
Ensembl
ENSG00000214253
Entrez Gene
51024
UniGene
423968
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FIS1
GeneCards
FIS1