Cell Senescence Entries for FOXA1

Cell Types
Uterus endometrium cancer
Cell Lines
HEC-1B, RL95-2
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Wang et al. (2017) Forkhead-box A1 induces cell senescence in endometrial cancer by regulating p16INK4a. Oncol Rep 36(2)795-802 (PubMed)

FOXA1 Gene Information

HGNC symbol
FOXA1 
Aliases
HNF3A 
Common name
forkhead box A1 
Entrez Id
3169
Description
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008].

FOXA1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:45944; positive regulation of transcription by RNA polymerase II
GO:43065; positive regulation of apoptotic process
GO:6338; chromatin remodeling
GO:6357; regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:9653; anatomical structure morphogenesis
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:33148; positive regulation of intracellular estrogen receptor signaling pathway
GO:10719; negative regulation of epithelial to mesenchymal transition
GO:71542; dopaminergic neuron differentiation
GO:45931; positive regulation of mitotic cell cycle
GO:2000049; positive regulation of cell-cell adhesion mediated by cadherin
GO:122; negative regulation of transcription by RNA polymerase II
GO:7219; Notch signaling pathway
GO:10468; regulation of gene expression
GO:21904; dorsal/ventral neural tube patterning
GO:30324; lung development
GO:32355; response to estradiol
GO:35239; tube morphogenesis
GO:42445; hormone metabolic process
GO:42593; glucose homeostasis
GO:45666; positive regulation of neuron differentiation
GO:45880; positive regulation of smoothened signaling pathway
GO:48646; anatomical structure formation involved in morphogenesis
GO:48665; neuron fate specification
GO:51726; regulation of cell cycle
GO:60425; lung morphogenesis
GO:60441; epithelial tube branching involved in lung morphogenesis
GO:60487; lung epithelial cell differentiation
GO:60528; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:60738; epithelial-mesenchymal signaling involved in prostate gland development
GO:60740; prostate gland epithelium morphogenesis
GO:60741; prostate gland stromal morphogenesis
GO:60743; epithelial cell maturation involved in prostate gland development
GO:61144; alveolar secondary septum development
GO:61448; connective tissue development
GO:1902691; respiratory basal cell differentiation
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:1650; fibrillar center
GO:785; chromatin
GO:5902; microvillus
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:19904; protein domain specific binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:3682; chromatin binding
GO:8134; transcription factor binding
Hide GO terms

Homologs of FOXA1 in Model Organisms

Danio rerio
foxa1
Drosophila melanogaster
fkh
Mus musculus
Foxa1
Rattus norvegicus
Foxa1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as fkh

External links

OMIM
602294
Ensembl
ENSG00000129514
Entrez Gene
3169
UniGene
163484
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOXA1
GeneCards
FOXA1