Cell Senescence Entries for FOXD1

Cell Types
Embryonic stem
Cell Lines
WA09
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative
Senescence Effect
Unclear
Primary Reference
Fu et al. (2020) Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS Biol 17(4)e3000201 (PubMed)

FOXD1 Gene Information

HGNC symbol
FOXD1 
Aliases
FKHL8; FREAC4 
Common name
forkhead box D1 
Entrez Id
2297
Description
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Studies of the orthologous mouse protein indicate that it functions in kidney development by promoting nephron progenitor differentiation, and it also functions in the development of the retina and optic chiasm. It may also regulate inflammatory reactions and prevent autoimmunity. [provided by RefSeq, Apr 2014].

FOXD1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:9653; anatomical structure morphogenesis
GO:10628; positive regulation of gene expression
GO:30513; positive regulation of BMP signaling pathway
GO:90184; positive regulation of kidney development
GO:1658; branching involved in ureteric bud morphogenesis
GO:1822; kidney development
GO:7411; axon guidance
GO:32275; luteinizing hormone secretion
GO:45944; positive regulation of transcription by RNA polymerase II
GO:60678; dichotomous subdivision of terminal units involved in ureteric bud branching
GO:72076; nephrogenic mesenchyme development
GO:72210; metanephric nephron development
GO:72213; metanephric capsule development
GO:72267; metanephric capsule specification
GO:72268; pattern specification involved in metanephros development
Cellular component: GO:5634; nucleus
GO:785; chromatin
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:8301; DNA binding, bending
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
Hide GO terms

Homologs of FOXD1 in Model Organisms

Danio rerio
foxd1
Mus musculus
Foxd1

External links

OMIM
601091
Ensembl
ENSG00000251493
Entrez Gene
2297
UniGene
519385
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOXD1
GeneCards
FOXD1