Cell Senescence Entries for FOXM1

Cell Types
Gallbladder cancer
Cell Lines
GBC-SD
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Tao et al. (2015) Down-regulation of FoxM1 inhibits viability and invasion of gallbladder carcinoma cells, partially dependent on inducement of cellular senescence. World J Gastroenterol 20(28)9497-505 (PubMed)

FOXM1 Gene Information

HGNC symbol
FOXM1 
Aliases
FKHL16; HFH-11; HNF-3; INS-1; MPHOSPH2; MPP2; TGT3; trident 
Common name
forkhead box M1 
Entrez Id
2305
Description
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].

FOXM1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:42127; regulation of cell population proliferation
GO:86; G2/M transition of mitotic cell cycle
GO:8284; positive regulation of cell population proliferation
GO:2000781; positive regulation of double-strand break repair
GO:122; negative regulation of transcription by RNA polymerase II
GO:45892; negative regulation of transcription, DNA-templated
GO:51726; regulation of cell cycle
GO:6978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:32873; negative regulation of stress-activated MAPK cascade
GO:46578; regulation of Ras protein signal transduction
GO:90344; negative regulation of cell aging
GO:2000377; regulation of reactive oxygen species metabolic process
GO:1558; regulation of cell growth
Cellular component: GO:5634; nucleus
GO:785; chromatin
GO:5654; nucleoplasm
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:19901; protein kinase binding
Hide GO terms

Homologs of FOXM1 in Model Organisms

Danio rerio
foxm1
Mus musculus
Foxm1
Rattus norvegicus
Foxm1

In other databases

GenAge human genes
  • This gene is present as FOXM1
CellAge gene expression
  • This gene is present as FOXM1

External links

OMIM
602341
Ensembl
ENSG00000111206
Entrez Gene
2305
UniGene
735243
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOXM1
GeneCards
FOXM1