Cell Senescence Entries for FOXO3

Cell Types
Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kyoung Kim et al. (2005) Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts. J Gerontol A Biol Sci Med Sci 60(1)4-9 (PubMed)

FOXO3 Gene Information

HGNC symbol
FOXO3 
Aliases
AF6q21; FKHRL1; FOXO2; FOXO3A 
Common name
forkhead box O3 
Entrez Id
2309
Description
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].

FOXO3 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:6417; regulation of translation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:33209; tumor necrosis factor-mediated signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:10508; positive regulation of autophagy
GO:34599; cellular response to oxidative stress
GO:122; negative regulation of transcription by RNA polymerase II
GO:6390; mitochondrial transcription
GO:43065; positive regulation of apoptotic process
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:70542; response to fatty acid
GO:30336; negative regulation of cell migration
GO:45591; positive regulation of regulatory T cell differentiation
GO:42149; cellular response to glucose starvation
GO:45648; positive regulation of erythrocyte differentiation
GO:14737; positive regulation of muscle atrophy
GO:42594; response to starvation
GO:43525; positive regulation of neuron apoptotic process
GO:1542; ovulation from ovarian follicle
GO:1544; initiation of primordial ovarian follicle growth
GO:1547; antral ovarian follicle growth
GO:1556; oocyte maturation
GO:7568; aging
GO:9410; response to xenobiotic stimulus
GO:30330; DNA damage response, signal transduction by p53 class mediator
GO:31667; response to nutrient levels
GO:42593; glucose homeostasis
GO:45665; negative regulation of neuron differentiation
GO:48854; brain morphogenesis
GO:71333; cellular response to glucose stimulus
GO:71386; cellular response to corticosterone stimulus
GO:71456; cellular response to hypoxia
GO:71548; response to dexamethasone
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:97150; neuronal stem cell population maintenance
GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
GO:1901300; positive regulation of hydrogen peroxide-mediated programmed cell death
GO:1903428; positive regulation of reactive oxygen species biosynthetic process
GO:1904646; cellular response to amyloid-beta
GO:1990090; cellular response to nerve growth factor stimulus
GO:1990785; response to water-immersion restraint stress
GO:2000177; regulation of neural precursor cell proliferation
GO:2000353; positive regulation of endothelial cell apoptotic process
GO:2000377; regulation of reactive oxygen species metabolic process
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:5741; mitochondrial outer membrane
GO:5829; cytosol
GO:785; chromatin
GO:90571; RNA polymerase II transcription repressor complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:31490; chromatin DNA binding
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:19901; protein kinase binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:976; transcription cis-regulatory region binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:8013; beta-catenin binding
GO:34246; mitochondrial transcription factor activity
GO:1221; transcription coregulator binding
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Homologs of FOXO3 in Model Organisms

Danio rerio
foxo3a
Mus musculus
Foxo3
Rattus norvegicus
Foxo3

In other databases

GenAge human genes
  • This gene is present as FOXO3
GenDR gene manipulations
  • A homolog of this gene for Mus musculus is present as Foxo3
LongevityMap
  • This gene is present as FOXO3

External links

OMIM
602681
Ensembl
ENSG00000118689
Entrez Gene
2309
UniGene
220950
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOXO3
GeneCards
FOXO3