Cell Senescence Entries for FXR1
- Cell Types
- Laryngeal cancer, Tongue cancer
- Cell Lines
- CAL27, SCC25, SCC4, SCC9, UM-SCC-11A, UM-SCC-11B, UM-SCC-74A, UM-SCC-74B
- Cancer Cell?
- Yes
- Method
- Knockdown, Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Majumder et al. (2017) RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC. PLoS Genet 12(9)e1006306 (PubMed)
FXR1 Gene Information
- HGNC symbol
- FXR1
- Aliases
- Common name
- FMR1 autosomal homolog 1
- Entrez Id
- 8087
- Description
- The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
FXR1 Ontologies
- Gene Ontology
-
Process: GO:6417; regulation of translation
GO:30154; cell differentiation
GO:7517; muscle organ development
GO:60538; skeletal muscle organ development
GO:381; regulation of alternative mRNA splicing, via spliceosome
GO:2000637; positive regulation of gene silencing by miRNA
GO:6915; apoptotic process
GO:1934; positive regulation of protein phosphorylation
GO:51489; regulation of filopodium assembly
GO:17148; negative regulation of translation
GO:43488; regulation of mRNA stability
GO:45727; positive regulation of translation
GO:2001022; positive regulation of response to DNA damage stimulus
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5634; nucleus
GO:36464; cytoplasmic ribonucleoprotein granule
GO:14069; postsynaptic density
GO:43025; neuronal cell body
GO:30424; axon
GO:98793; presynapse
GO:5730; nucleolus
GO:5844; polysome
GO:43197; dendritic spine
GO:30426; growth cone
GO:44326; dendritic spine neck
GO:1902737; dendritic filopodium
GO:30425; dendrite
GO:35770; ribonucleoprotein granule
GO:43034; costamere
GO:48471; perinuclear region of cytoplasm
GO:98794; postsynapse
GO:98978; glutamatergic synapse
Function: GO:3729; mRNA binding
GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:3730; mRNA 3'-UTR binding
GO:46982; protein heterodimerization activity
GO:33592; RNA strand annealing activity
GO:45182; translation regulator activity
Homologs of FXR1 in Model Organisms
- Danio rerio
- fxr1
- Drosophila melanogaster
- Fmr1
- Mus musculus
- Fxr1
- Rattus norvegicus
- LOC100366044
External links
- OMIM
- 600819
- Ensembl
- ENSG00000114416
- Entrez Gene
- 8087
- UniGene
- 478407
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- FXR1
- GeneCards
- FXR1