Cell Senescence Entries for G6PD

Cell Types
Foreskin fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Ho et al. (2000) Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. Free Radic Biol Med 29(2)156-69 (PubMed)

G6PD Gene Information

HGNC symbol
G6PD 
Aliases
G6PD1 
Common name
glucose-6-phosphate dehydrogenase 
Entrez Id
2539
Description
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

G6PD Ontologies

Gene Ontology
Process: GO:6006; glucose metabolic process
GO:5975; carbohydrate metabolic process
GO:19637; organophosphate metabolic process
GO:6098; pentose-phosphate shunt
GO:6739; NADP metabolic process
GO:21762; substantia nigra development
GO:6629; lipid metabolic process
GO:9051; pentose-phosphate shunt, oxidative branch
GO:51156; glucose 6-phosphate metabolic process
GO:6749; glutathione metabolic process
GO:6695; cholesterol biosynthetic process
GO:6740; NADPH regeneration
GO:10734; negative regulation of protein glutathionylation
GO:19322; pentose biosynthetic process
GO:34599; cellular response to oxidative stress
GO:43249; erythrocyte maturation
GO:46390; ribose phosphate biosynthetic process
GO:10041; response to iron(III) ion
GO:14070; response to organic cyclic compound
GO:32094; response to food
GO:43523; regulation of neuron apoptotic process
GO:45471; response to ethanol
GO:61052; negative regulation of cell growth involved in cardiac muscle cell development
GO:1904879; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:2000378; negative regulation of reactive oxygen species metabolic process
Cellular component: GO:5829; cytosol
GO:34451; centriolar satellite
GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:70062; extracellular exosome
GO:9898; cytoplasmic side of plasma membrane
GO:5634; nucleus
Function: GO:16614; oxidoreductase activity, acting on CH-OH group of donors
GO:50661; NADP binding
GO:4345; glucose-6-phosphate dehydrogenase activity
GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:5536; glucose binding
GO:30246; carbohydrate binding
Hide GO terms

Homologs of G6PD in Model Organisms

Caenorhabditis elegans
gspd-1
Danio rerio
g6pd
Drosophila melanogaster
Zw
Mus musculus
G6pdx
Rattus norvegicus
G6pdx
Saccharomyces cerevisiae
ZWF1
Schizosaccharomyces pombe
zwf1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Zw
  • A homolog of this gene for Saccharomyces cerevisiae is present as ZWF1
  • A homolog of this gene for Mus musculus is present as G6PD
GenDR gene expression
  • A homolog of this gene for Mus musculus is present as G6pdx
LongevityMap
  • This gene is present as G6PD

External links

OMIM
305900
Ensembl
ENSG00000160211
Entrez Gene
2539
UniGene
684904
1000 Genomes
1000 Genomes
HPRD
GenAtlas
G6PD
GeneCards
G6PD