Cell Senescence Entries for GADD45G
- Cell Types
- Liver cancer
- Cell Lines
- Hep3B, SK-HEP-1, SMMC-7721
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Primary Reference
- Zhang et al. (2014) Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma. Hepatology 59(1)178-89 (PubMed)
GADD45G Gene Information
- HGNC symbol
- GADD45G
- Aliases
- CR6; DDIT2; GADD45gamma; GRP17
- Common name
- growth arrest and DNA damage inducible gamma
- Entrez Id
- 10912
- Description
- This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008].
GADD45G Ontologies
- Gene Ontology
-
Process: GO:6915; apoptotic process
GO:30154; cell differentiation
GO:43065; positive regulation of apoptotic process
GO:51726; regulation of cell cycle
GO:120162; positive regulation of cold-induced thermogenesis
GO:46330; positive regulation of JNK cascade
GO:1900745; positive regulation of p38MAPK cascade
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
Hide GO termsFunction: GO:5515; protein binding
Homologs of GADD45G in Model Organisms
External links
- OMIM
- 604949
- Ensembl
- ENSG00000130222
- Entrez Gene
- 10912
- UniGene
- 9701
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- GADD45G
- GeneCards
- GADD45G