Cell Senescence Entries for GATA4

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Kang et al. (2015) The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science 349(6255)aaa5612 (PubMed)

GATA4 Gene Information

HGNC symbol
GATA4 
Aliases
 
Common name
GATA binding protein 4 
Entrez Id
2626
Description
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].

GATA4 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:8584; male gonad development
GO:45766; positive regulation of angiogenesis
GO:3281; ventricular septum development
GO:1947; heart looping
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:45165; cell fate commitment
GO:36302; atrioventricular canal development
GO:42060; wound healing
GO:3180; aortic valve morphogenesis
GO:7267; cell-cell signaling
GO:10575; positive regulation of vascular endothelial growth factor production
GO:3197; endocardial cushion development
GO:9410; response to xenobiotic stimulus
GO:3208; cardiac ventricle morphogenesis
GO:3215; cardiac right ventricle morphogenesis
GO:60575; intestinal epithelial cell differentiation
GO:3162; atrioventricular node development
GO:3190; atrioventricular valve formation
GO:3289; atrial septum primum morphogenesis
GO:3290; atrial septum secundum morphogenesis
GO:7492; endoderm development
GO:10667; negative regulation of cardiac muscle cell apoptotic process
GO:35054; embryonic heart tube anterior/posterior pattern specification
GO:48617; embryonic foregut morphogenesis
GO:51891; positive regulation of cardioblast differentiation
GO:51896; regulation of protein kinase B signaling
GO:60413; atrial septum morphogenesis
GO:61026; cardiac muscle tissue regeneration
GO:1903202; negative regulation of oxidative stress-induced cell death
GO:2001234; negative regulation of apoptotic signaling pathway
GO:30154; cell differentiation
GO:48513; animal organ development
GO:7596; blood coagulation
GO:9653; anatomical structure morphogenesis
GO:9612; response to mechanical stimulus
GO:10507; negative regulation of autophagy
GO:30513; positive regulation of BMP signaling pathway
GO:33189; response to vitamin A
GO:55007; cardiac muscle cell differentiation
GO:60290; transdifferentiation
GO:61049; cell growth involved in cardiac muscle cell development
GO:71333; cellular response to glucose stimulus
GO:86004; regulation of cardiac muscle cell contraction
GO:7507; heart development
Cellular component: GO:5634; nucleus
GO:16604; nuclear body
GO:785; chromatin
GO:5654; nucleoplasm
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:5515; protein binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:70410; co-SMAD binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:1216; DNA-binding transcription activator activity
GO:987; cis-regulatory region sequence-specific DNA binding
GO:19901; protein kinase binding
GO:51525; NFAT protein binding
GO:140297; DNA-binding transcription factor binding
Hide GO terms

Homologs of GATA4 in Model Organisms

Danio rerio
gata4
Mus musculus
Gata4
Rattus norvegicus
Gata4

In other databases

LongevityMap
  • This gene is present as GATA4

External links

OMIM
600576
Ensembl
ENSG00000136574
Entrez Gene
2626
UniGene
243987
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GATA4
GeneCards
GATA4