Cell Senescence Entries for GDF15
- Cell Types
- Aortic endothelial
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Oncogene-induced, Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Park et al. (2016) GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells. Oncotarget 7(9)9634-44 (PubMed)
GDF15 Gene Information
- HGNC symbol
- GDF15
- Aliases
- MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB
- Common name
- growth differentiation factor 15
- Entrez Id
- 9518
- Description
- This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016].
GDF15 Ontologies
- Gene Ontology
-
Process: GO:35860; glial cell-derived neurotrophic factor receptor signaling pathway
GO:51897; positive regulation of protein kinase B signaling
GO:30509; BMP signaling pathway
GO:43410; positive regulation of MAPK cascade
GO:60395; SMAD protein signal transduction
GO:7165; signal transduction
GO:7267; cell-cell signaling
GO:10862; positive regulation of pathway-restricted SMAD protein phosphorylation
GO:60400; negative regulation of growth hormone receptor signaling pathway
GO:7179; transforming growth factor beta receptor signaling pathway
GO:40015; negative regulation of multicellular organism growth
GO:2023; reduction of food intake in response to dietary excess
GO:1901741; positive regulation of myoblast fusion
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5794; Golgi apparatus
GO:5576; extracellular region
GO:5615; extracellular space
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
Function: GO:8083; growth factor activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:5125; cytokine activity
GO:70700; BMP receptor binding
Homologs of GDF15 in Model Organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Gdf15
- CellAge gene expression
- This gene is present as GDF15
External links
- OMIM
- 605312
- Ensembl
- ENSG00000130513
- Entrez Gene
- 9518
- UniGene
- 616962
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- GDF15
- GeneCards
- GDF15