Cell Senescence Entries for GLI1

Cell Types
Glioblastoma
Cell Lines
T98G, U-87MG
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Melamed et al. (2019) Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide. Oncotarget 9(43)27000-27015 (PubMed)

GLI1 Gene Information

HGNC symbol
GLI1 
Aliases
GLI 
Common name
GLI family zinc finger 1 
Entrez Id
2735
Description
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].

GLI1 Ontologies

Gene Ontology
Process: GO:6357; regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:8284; positive regulation of cell population proliferation
GO:7224; smoothened signaling pathway
GO:21983; pituitary gland development
GO:45880; positive regulation of smoothened signaling pathway
GO:45740; positive regulation of DNA replication
GO:1649; osteoblast differentiation
GO:60045; positive regulation of cardiac muscle cell proliferation
GO:7283; spermatogenesis
GO:7418; ventral midline development
GO:8589; regulation of smoothened signaling pathway
GO:9611; response to wounding
GO:9913; epidermal cell differentiation
GO:9953; dorsal/ventral pattern formation
GO:9954; proximal/distal pattern formation
GO:21696; cerebellar cortex morphogenesis
GO:21938; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:30324; lung development
GO:30850; prostate gland development
GO:45667; regulation of osteoblast differentiation
GO:48546; digestive tract morphogenesis
GO:60032; notochord regression
GO:60070; canonical Wnt signaling pathway
GO:97421; liver regeneration
GO:1902808; positive regulation of cell cycle G1/S phase transition
GO:1990787; negative regulation of hh target transcription factor activity
GO:2000345; regulation of hepatocyte proliferation
GO:30335; positive regulation of cell migration
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:97542; ciliary tip
GO:97546; ciliary base
GO:1990788; GLI-SUFU complex
GO:5929; cilium
GO:5930; axoneme
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:3682; chromatin binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:8017; microtubule binding
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Homologs of GLI1 in Model Organisms

Mus musculus
Gli1
Rattus norvegicus
Gli1

External links

OMIM
165220
Ensembl
ENSG00000111087
Entrez Gene
2735
UniGene
632702
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GLI1
GeneCards
GLI1