Cell Senescence Entries for GMPS
- Cell Types
- Liver cancer
- Cell Lines
- Hep G2, HuH6, SK-HEP-1
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Holzer et al. (2017) Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer. Am J Pathol 187(2)228-235 (PubMed)
GMPS Gene Information
- HGNC symbol
- GMPS
- Aliases
- GATD7
- Common name
- guanine monophosphate synthase
- Entrez Id
- 8833
- Description
- In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008].
GMPS Ontologies
- Gene Ontology
-
Process: GO:6164; purine nucleotide biosynthetic process
GO:6541; glutamine metabolic process
GO:6177; GMP biosynthetic process
GO:46037; GMP metabolic process
GO:9168; purine ribonucleoside monophosphate biosynthetic process
GO:9113; purine nucleobase biosynthetic process
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
Hide GO termsFunction: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16874; ligase activity
GO:16462; pyrophosphatase activity
GO:3922; GMP synthase (glutamine-hydrolyzing) activity
GO:3921; GMP synthase activity
Homologs of GMPS in Model Organisms
- Caenorhabditis elegans
- M106.4
- Danio rerio
- gmps
- Drosophila melanogaster
- bur
- Mus musculus
- Gmps
- Rattus norvegicus
- Gmps
- Saccharomyces cerevisiae
- GUA1
- Schizosaccharomyces pombe
- gua1
In other databases
- CellAge gene expression
- This gene is present as GMPS
External links
- OMIM
- 600358
- Ensembl
- ENSG00000163655
- Entrez Gene
- 8833
- UniGene
- 591314
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- GMPS
- GeneCards
- GMPS