Cell Senescence Entries for GNMT
- Cell Types
- Liver cancer
- Cell Lines
- Hep G2, Huh7
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Yen et al. (2012) Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma. Mol Med 18(2)286-96 (PubMed)
GNMT Gene Information
- HGNC symbol
- GNMT
- Aliases
- Common name
- glycine N-methyltransferase
- Entrez Id
- 27232
- Description
- The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. This protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between the upstream CNPY3 (canopy FGF signaling regulator 3) gene and this gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016].
GNMT Ontologies
- Gene Ontology
-
Process: GO:32259; methylation
GO:19752; carboxylic acid metabolic process
GO:6464; cellular protein modification process
GO:51289; protein homotetramerization
GO:6730; one-carbon metabolic process
GO:5977; glycogen metabolic process
GO:6111; regulation of gluconeogenesis
GO:6555; methionine metabolic process
GO:46498; S-adenosylhomocysteine metabolic process
GO:46500; S-adenosylmethionine metabolic process
GO:1901052; sarcosine metabolic process
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
Hide GO termsFunction: GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:5542; folic acid binding
GO:8757; S-adenosylmethionine-dependent methyltransferase activity
GO:16594; glycine binding
GO:17174; glycine N-methyltransferase activity
GO:1904047; S-adenosyl-L-methionine binding
Homologs of GNMT in Model Organisms
- Danio rerio
- gnmt
- Drosophila melanogaster
- CG6188
- Mus musculus
- Gnmt
- Rattus norvegicus
- LOC100911564
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Gnmt
External links
- OMIM
- 606628
- Ensembl
- ENSG00000124713
- Entrez Gene
- 27232
- UniGene
- 144914
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- GNMT
- GeneCards
- GNMT