Cell Senescence Entries for GPC3

Cell Types
Liver cancer
Cell Lines
Hep G2, Huh7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Sun et al. (2011) Suppression of glypican 3 inhibits growth of hepatocellular carcinoma cells through up-regulation of TGF-β2. Neoplasia 13(8)735-47 (PubMed)

GPC3 Gene Information

HGNC symbol
GPC3 
Aliases
DGSX; OCI-5; SDYS; SGB; SGBS; SGBS1 
Common name
glypican 3 
Entrez Id
2719
Description
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].

GPC3 Ontologies

Gene Ontology
Process: GO:6024; glycosaminoglycan biosynthetic process
GO:6027; glycosaminoglycan catabolic process
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:9966; regulation of signal transduction
GO:1523; retinoid metabolic process
GO:10466; negative regulation of peptidase activity
GO:16477; cell migration
GO:45732; positive regulation of protein catabolic process
GO:1658; branching involved in ureteric bud morphogenesis
GO:1822; kidney development
GO:8285; negative regulation of cell population proliferation
GO:9617; response to bacterium
GO:9887; animal organ morphogenesis
GO:9948; anterior/posterior axis specification
GO:10171; body morphogenesis
GO:30282; bone mineralization
GO:30316; osteoclast differentiation
GO:30324; lung development
GO:30513; positive regulation of BMP signaling pathway
GO:35116; embryonic hindlimb morphogenesis
GO:40008; regulation of growth
GO:45807; positive regulation of endocytosis
GO:45879; negative regulation of smoothened signaling pathway
GO:45880; positive regulation of smoothened signaling pathway
GO:45926; negative regulation of growth
GO:46326; positive regulation of glucose import
GO:50680; negative regulation of epithelial cell proliferation
GO:60976; coronary vasculature development
GO:72111; cell proliferation involved in kidney development
GO:72138; mesenchymal cell proliferation involved in ureteric bud development
GO:72180; mesonephric duct morphogenesis
GO:72203; cell proliferation involved in metanephros development
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:2000096; positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:9653; anatomical structure morphogenesis
GO:1905475; regulation of protein localization to membrane
GO:60828; regulation of canonical Wnt signaling pathway
GO:42074; cell migration involved in gastrulation
GO:2000050; regulation of non-canonical Wnt signaling pathway
Cellular component: GO:16020; membrane
GO:5886; plasma membrane
GO:31225; anchored component of membrane
GO:43202; lysosomal lumen
GO:62023; collagen-containing extracellular matrix
GO:46658; anchored component of plasma membrane
GO:9986; cell surface
GO:5764; lysosome
GO:31226; intrinsic component of plasma membrane
GO:5788; endoplasmic reticulum lumen
GO:5796; Golgi lumen
Function: GO:5515; protein binding
GO:30414; peptidase inhibitor activity
GO:60422; peptidyl-dipeptidase inhibitor activity
Hide GO terms

Homologs of GPC3 in Model Organisms

Danio rerio
gpc3
Drosophila melanogaster
dally
Mus musculus
Gpc3
Rattus norvegicus
Gpc3

External links

OMIM
300037
Ensembl
ENSG00000147257
Entrez Gene
2719
UniGene
644108
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GPC3
GeneCards
GPC3