Cell Senescence Entries for GRK4

Cell Types
Embryonic kidney
Cell Lines
HEK293
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Xiao et al. (2017) G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. Exp Cell Res 360(2)273-280 (PubMed)

GRK4 Gene Information

HGNC symbol
GRK4 
Aliases
GPRK2L; GPRK4 
Common name
G protein-coupled receptor kinase 4 
Entrez Id
2868
Description
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].

GRK4 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:7165; signal transduction
GO:31623; receptor internalization
GO:8277; regulation of G protein-coupled receptor signaling pathway
GO:22400; regulation of rhodopsin mediated signaling pathway
GO:9966; regulation of signal transduction
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5938; cell cortex
GO:97381; photoreceptor disc membrane
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4703; G protein-coupled receptor kinase activity
GO:50254; rhodopsin kinase activity
Hide GO terms

Homologs of GRK4 in Model Organisms

Caenorhabditis elegans
grk-1
Danio rerio
grk4
Drosophila melanogaster
Gprk2
Mus musculus
Grk4
Rattus norvegicus
Grk4

External links

OMIM
137026
Ensembl
ENSG00000125388
Entrez Gene
2868
UniGene
32959
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GRK4
GeneCards
GRK4