The GSK3B gene and its putative association with human ageing

Cell Types

Cervical cancer

Cell Lines

HeLa

Cancer Cell?

Yes

Method

Knockdown, Mutation

Type of senescence

Unclear

Senescence Effect

Inhibits

Primary Reference

Seo et al. (2009) Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation. Aging Cell 7(6)894-907 (PubMed)

HGNC symbol

GSK3B

Aliases

Common name

glycogen synthase kinase 3 beta

Entrez Id

2932

Description

The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017].

Gene Ontology

Process:

GO:10629; negative regulation of gene expression
GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:5975; carbohydrate metabolic process
GO:30154; cell differentiation
GO:9968; negative regulation of signal transduction
GO:5977; glycogen metabolic process
GO:16055; Wnt signaling pathway
GO:51093; negative regulation of developmental process
GO:51128; regulation of cellular component organization
GO:7399; nervous system development
GO:7623; circadian rhythm
GO:48511; rhythmic process
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:46777; protein autophosphorylation
GO:7165; signal transduction
GO:10508; positive regulation of autophagy
GO:8286; insulin receptor signaling pathway
GO:10975; regulation of neuron projection development
GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
GO:43547; positive regulation of GTPase activity
GO:31334; positive regulation of protein-containing complex assembly
GO:10628; positive regulation of gene expression
GO:1904646; cellular response to amyloid-beta
GO:32092; positive regulation of protein binding
GO:1902042; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1954; positive regulation of cell-matrix adhesion
GO:42752; regulation of circadian rhythm
GO:32091; negative regulation of protein binding
GO:31175; neuron projection development
GO:45732; positive regulation of protein catabolic process
GO:18105; peptidyl-serine phosphorylation
GO:35556; intracellular signal transduction
GO:45724; positive regulation of cilium assembly
GO:10822; positive regulation of mitochondrion organization
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:32886; regulation of microtubule-based process
GO:18107; peptidyl-threonine phosphorylation
GO:1900034; regulation of cellular response to heat
GO:70507; regulation of microtubule cytoskeleton organization
GO:1837; epithelial to mesenchymal transition
GO:1903566; positive regulation of protein localization to cilium
GO:36016; cellular response to interleukin-3
GO:6983; ER overload response
GO:1901216; positive regulation of neuron death
GO:30010; establishment of cell polarity
GO:19082; viral protein processing
GO:71300; cellular response to retinoic acid
GO:43066; negative regulation of apoptotic process
GO:31333; negative regulation of protein-containing complex assembly
GO:60079; excitatory postsynaptic potential
GO:1901215; negative regulation of neuron death
GO:45597; positive regulation of cell differentiation
GO:7212; dopamine receptor signaling pathway
GO:1900271; regulation of long-term synaptic potentiation
GO:21766; hippocampus development
GO:45719; negative regulation of glycogen biosynthetic process
GO:97191; extrinsic apoptotic signaling pathway
GO:1901030; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000077; negative regulation of type B pancreatic cell development
GO:2000466; negative regulation of glycogen (starch) synthase activity
GO:46827; positive regulation of protein export from nucleus
GO:30011; maintenance of cell polarity
GO:30516; regulation of axon extension
GO:32515; negative regulation of phosphoprotein phosphatase activity
GO:46825; regulation of protein export from nucleus
GO:48814; regulation of dendrite morphogenesis
GO:50770; regulation of axonogenesis
GO:70885; negative regulation of calcineurin-NFAT signaling cascade
GO:71109; superior temporal gyrus development
GO:106027; neuron projection organization
GO:150101; regulation of microtubule anchoring at centrosome
GO:1900181; negative regulation of protein localization to nucleus
GO:1901984; negative regulation of protein acetylation
GO:1904339; negative regulation of dopaminergic neuron differentiation
GO:1904781; positive regulation of protein localization to centrosome
GO:1904886; beta-catenin destruction complex disassembly
GO:1905240; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation
GO:2000300; regulation of synaptic vesicle exocytosis
GO:2000740; negative regulation of mesenchymal stem cell differentiation
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular component:

GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5813; centrosome
GO:98794; postsynapse
GO:5829; cytosol
GO:30424; axon
GO:30877; beta-catenin destruction complex
GO:30425; dendrite
GO:98978; glutamatergic synapse
GO:1990909; Wnt signalosome
GO:16021; integral component of membrane

Function:

GO:5515; protein binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:50321; tau-protein kinase activity
GO:19901; protein kinase binding
GO:8013; beta-catenin binding
GO:48156; tau protein binding
GO:31625; ubiquitin protein ligase binding
GO:51059; NF-kappaB binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:2020; protease binding
GO:34236; protein kinase A catalytic subunit binding
GO:2039; p53 binding
GO:34452; dynactin binding

Hide GO terms

Danio rerio

gsk3b

Drosophila melanogaster

sgg

Mus musculus

Gsk3b

Rattus norvegicus

Gsk3b

Saccharomyces cerevisiae

MRK1

GenAge human genes