Cell Senescence Entries for GTSE1
- Cell Types
- Breast cancer
- Cell Lines
- MDA-MB-231
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Lin et al. (2019) GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner. J Exp Clin Cancer Res 38(1)152 (PubMed)
GTSE1 Gene Information
- HGNC symbol
- GTSE1
- Aliases
- B99; GTSE-1; Lnc_bc060912
- Common name
- G2 and S-phase expressed 1
- Entrez Id
- 51512
- Description
- The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008].
GTSE1 Ontologies
- Gene Ontology
-
Process: GO:7017; microtubule-based process
GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5856; cytoskeleton
GO:5874; microtubule
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5881; cytoplasmic microtubule
GO:15630; microtubule cytoskeleton
Hide GO termsFunction: GO:5515; protein binding
GO:3674; molecular_function
GO:8017; microtubule binding
Homologs of GTSE1 in Model Organisms
- Danio rerio
- zgc:110687
- Mus musculus
- Gtse1
- Rattus norvegicus
- Gtse1
In other databases
- CellAge gene expression
- This gene is present as GTSE1
External links
- OMIM
- 607477
- Ensembl
- ENSG00000075218
- Entrez Gene
- 51512
- UniGene
- 439524
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- GTSE1
- GeneCards
- GTSE1