Cell Senescence Entries for HDAC2

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Harms et al. (2007) Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity. Cancer Res 67(7)3145-52 (PubMed)

HDAC2 Gene Information

HGNC symbol
HDAC2 
Aliases
KDAC2; RPD3; YAF1 
Common name
histone deacetylase 2 
Entrez Id
3066
Description
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].

HDAC2 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:16575; histone deacetylation
GO:48511; rhythmic process
GO:32922; circadian regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:6338; chromatin remodeling
GO:8284; positive regulation of cell population proliferation
GO:43066; negative regulation of apoptotic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:16358; dendrite development
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:45892; negative regulation of transcription, DNA-templated
GO:42733; embryonic digit morphogenesis
GO:70932; histone H3 deacetylation
GO:2000273; positive regulation of signaling receptor activity
GO:32967; positive regulation of collagen biosynthetic process
GO:45347; negative regulation of MHC class II biosynthetic process
GO:42475; odontogenesis of dentin-containing tooth
GO:70828; heterochromatin organization
GO:10977; negative regulation of neuron projection development
GO:45862; positive regulation of proteolysis
GO:70933; histone H4 deacetylation
GO:9913; epidermal cell differentiation
GO:60789; hair follicle placode formation
GO:61029; eyelid development in camera-type eye
GO:61198; fungiform papilla formation
GO:1975; response to amphetamine
GO:3300; cardiac muscle hypertrophy
GO:9410; response to xenobiotic stimulus
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:31000; response to caffeine
GO:32496; response to lipopolysaccharide
GO:32732; positive regulation of interleukin-1 production
GO:32760; positive regulation of tumor necrosis factor production
GO:34605; cellular response to heat
GO:35094; response to nicotine
GO:42220; response to cocaine
GO:42531; positive regulation of tyrosine phosphorylation of STAT protein
GO:43392; negative regulation of DNA binding
GO:48149; behavioral response to ethanol
GO:48714; positive regulation of oligodendrocyte differentiation
GO:55093; response to hyperoxia
GO:61000; negative regulation of dendritic spine development
GO:70301; cellular response to hydrogen peroxide
GO:71300; cellular response to retinoic acid
GO:71560; cellular response to transforming growth factor beta stimulus
GO:1902437; positive regulation of male mating behavior
GO:1903351; cellular response to dopamine
GO:2000757; negative regulation of peptidyl-lysine acetylation
GO:30336; negative regulation of cell migration
GO:1902459; positive regulation of stem cell population maintenance
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:1902455; negative regulation of stem cell population maintenance
GO:42659; regulation of cell fate specification
GO:2000736; regulation of stem cell differentiation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:785; chromatin
GO:781; chromosome, telomeric region
GO:118; histone deacetylase complex
GO:35098; ESC/E(Z) complex
GO:16581; NuRD complex
GO:16580; Sin3 complex
GO:16020; membrane
GO:16021; integral component of membrane
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:16787; hydrolase activity
GO:19899; enzyme binding
GO:4407; histone deacetylase activity
GO:42826; histone deacetylase binding
GO:3682; chromatin binding
GO:19213; deacetylase activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:33558; protein deacetylase activity
GO:51059; NF-kappaB binding
GO:43565; sequence-specific DNA binding
GO:31492; nucleosomal DNA binding
GO:31072; heat shock protein binding
GO:1990841; promoter-specific chromatin binding
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Homologs of HDAC2 in Model Organisms

Caenorhabditis elegans
hda-1
Mus musculus
Hdac2
Rattus norvegicus
Hdac2
Schizosaccharomyces pombe
clr6

In other databases

GenAge human genes
  • This gene is present as HDAC2

External links

OMIM
605164
Ensembl
ENSG00000196591
Entrez Gene
3066
UniGene
3352
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HDAC2
GeneCards
HDAC2