Cell Senescence Entries for HDAC4

Cell Types
Lung fibroblast
Cell Lines
2BS
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Han et al. (2016) HDAC4 stabilizes SIRT1 via sumoylation SIRT1 to delay cellular senescence. Clin Exp Pharmacol Physiol 43(1)41-6 (PubMed)

HDAC4 Gene Information

HGNC symbol
HDAC4 
Aliases
BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDACA; KIAA0288 
Common name
histone deacetylase 4 
Entrez Id
9759
Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008].

HDAC4 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:6476; protein deacetylation
GO:16575; histone deacetylation
GO:7399; nervous system development
GO:6954; inflammatory response
GO:16925; protein sumoylation
GO:8284; positive regulation of cell population proliferation
GO:42113; B cell activation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:45892; negative regulation of transcription, DNA-templated
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:6338; chromatin remodeling
GO:14898; cardiac muscle hypertrophy in response to stress
GO:70555; response to interleukin-1
GO:40029; regulation of gene expression, epigenetic
GO:45820; negative regulation of glycolytic process
GO:33235; positive regulation of protein sumoylation
GO:30183; B cell differentiation
GO:43393; regulation of protein binding
GO:10832; negative regulation of myotube differentiation
GO:14894; response to denervation involved in regulation of muscle adaptation
GO:34983; peptidyl-lysine deacetylation
GO:70932; histone H3 deacetylation
GO:70933; histone H4 deacetylation
GO:50896; response to stimulus
GO:19222; regulation of metabolic process
GO:1501; skeletal system development
GO:2076; osteoblast development
GO:8285; negative regulation of cell population proliferation
GO:9410; response to xenobiotic stimulus
GO:10592; positive regulation of lamellipodium assembly
GO:10882; regulation of cardiac muscle contraction by calcium ion signaling
GO:14911; positive regulation of smooth muscle cell migration
GO:43525; positive regulation of neuron apoptotic process
GO:45668; negative regulation of osteoblast differentiation
GO:48661; positive regulation of smooth muscle cell proliferation
GO:48742; regulation of skeletal muscle fiber development
GO:51153; regulation of striated muscle cell differentiation
GO:71260; cellular response to mechanical stimulus
GO:71356; cellular response to tumor necrosis factor
GO:71374; cellular response to parathyroid hormone stimulus
GO:1902437; positive regulation of male mating behavior
GO:1902894; negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1903428; positive regulation of reactive oxygen species biosynthetic process
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:5829; cytosol
GO:118; histone deacetylase complex
GO:17053; transcription repressor complex
GO:30017; sarcomere
GO:30018; Z disc
GO:31594; neuromuscular junction
GO:31672; A band
GO:32991; protein-containing complex
GO:42641; actomyosin
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:42802; identical protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:4407; histone deacetylase activity
GO:19789; SUMO transferase activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:976; transcription cis-regulatory region binding
GO:33558; protein deacetylase activity
GO:42826; histone deacetylase binding
GO:43565; sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:8270; zinc ion binding
GO:30955; potassium ion binding
GO:3677; DNA binding
GO:3682; chromatin binding
GO:3714; transcription corepressor activity
GO:19901; protein kinase binding
GO:1990841; promoter-specific chromatin binding
Hide GO terms

Homologs of HDAC4 in Model Organisms

Danio rerio
hdac4
Drosophila melanogaster
HDAC4
Mus musculus
Hdac4
Rattus norvegicus
Hdac4

External links

OMIM
605314
Ensembl
ENSG00000068024
Entrez Gene
9759
UniGene
20516
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HDAC4
GeneCards
HDAC4