Cell Senescence Entries for HDAC7

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Zhu et al. (2011) The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc. J Mol Med (Berl) 89(3)279-89 (PubMed)

HDAC7 Gene Information

HGNC symbol
HDAC7 
Aliases
DKFZP586J0917; HDAC7A 
Common name
histone deacetylase 7 
Entrez Id
51564
Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

HDAC7 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:6476; protein deacetylation
GO:16575; histone deacetylation
GO:16925; protein sumoylation
GO:90050; positive regulation of cell migration involved in sprouting angiogenesis
GO:1901223; negative regulation of NIK/NF-kappaB signaling
GO:45668; negative regulation of osteoblast differentiation
GO:32703; negative regulation of interleukin-2 production
GO:122; negative regulation of transcription by RNA polymerase II
GO:1570; vasculogenesis
GO:7043; cell-cell junction assembly
GO:45892; negative regulation of transcription, DNA-templated
GO:19222; regulation of metabolic process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:118; histone deacetylase complex
GO:5654; nucleoplasm
Function: GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:5515; protein binding
GO:4407; histone deacetylase activity
GO:140297; DNA-binding transcription factor binding
GO:19901; protein kinase binding
GO:19789; SUMO transferase activity
GO:71889; 14-3-3 protein binding
GO:33558; protein deacetylase activity
GO:5080; protein kinase C binding
GO:3682; chromatin binding
GO:3714; transcription corepressor activity
Hide GO terms

Homologs of HDAC7 in Model Organisms

Caenorhabditis elegans
hda-4
Mus musculus
Hdac7

External links

OMIM
606542
Ensembl
ENSG00000061273
Entrez Gene
51564
UniGene
200063
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HDAC7
GeneCards
HDAC7