Cell Senescence Entries for HELLS
- Cell Types
- Lung fibroblast
- Cell Lines
- 2BS
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Zhou et al. (2009) Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts. Nucleic Acids Res 37(15)5183-96 (PubMed)
HELLS Gene Information
- HGNC symbol
- HELLS
- Aliases
- LSH; Nbla10143; PASG; SMARCA6
- Common name
- helicase, lymphoid specific
- Entrez Id
- 3070
- Description
- This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014].
HELLS Ontologies
- Gene Ontology
-
Process: GO:6338; chromatin remodeling
GO:7049; cell cycle
GO:51301; cell division
GO:1822; kidney development
GO:10216; maintenance of DNA methylation
GO:46651; lymphocyte proliferation
GO:31508; pericentric heterochromatin assembly
GO:6346; DNA methylation-dependent heterochromatin assembly
GO:1655; urogenital system development
GO:6306; DNA methylation
GO:31507; heterochromatin assembly
GO:43066; negative regulation of apoptotic process
GO:1990830; cellular response to leukemia inhibitory factor
GO:2001243; negative regulation of intrinsic apoptotic signaling pathway
Cellular component: GO:5634; nucleus
GO:775; chromosome, centromeric region
GO:5721; pericentric heterochromatin
Hide GO termsFunction: GO:166; nucleotide binding
GO:5524; ATP binding
GO:4386; helicase activity
GO:140658; ATP-dependent chromatin remodeler activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:3682; chromatin binding
Homologs of HELLS in Model Organisms
- Danio rerio
- hells
- Mus musculus
- Hells
- Rattus norvegicus
- LOC100911660
- Saccharomyces cerevisiae
- IRC5
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Hells
- GenAge human genes
- This gene is present as HELLS
- CellAge gene expression
- This gene is present as HELLS
External links
- OMIM
- 603946
- Ensembl
- ENSG00000119969
- Entrez Gene
- 3070
- UniGene
- 655830
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HELLS
- GeneCards
- HELLS