The HIF1A gene and its putative association with human ageing

Cell Types

Endometrial adenocarcinoma, Neuroblastoma

Cell Lines

HHUA, HWCA, Ishikawa, SK-N-BE(2)-C

Cancer Cell?

Yes

Method

Knockdown

Type of senescence

Stress-induced

Senescence Effect

Inhibits

Primary Reference

Cimmino et al. (2016) Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells. Sci Rep 5(2)11158 (PubMed)

HGNC symbol

HIF1A

Aliases

bHLHe78; HIF-1alpha; HIF1; MOP1; PASD8

Common name

hypoxia inducible factor 1 subunit alpha

Entrez Id

3091

Description

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011].

Gene Ontology

Process:

GO:10628; positive regulation of gene expression
GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:33554; cellular response to stress
GO:10468; regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:98586; cellular response to virus
GO:1666; response to hypoxia
GO:1525; angiogenesis
GO:1568; blood vessel development
GO:1755; neural crest cell migration
GO:1837; epithelial to mesenchymal transition
GO:1892; embryonic placenta development
GO:1922; B-1 B cell homeostasis
GO:1944; vasculature development
GO:1947; heart looping
GO:2052; positive regulation of neuroblast proliferation
GO:2248; connective tissue replacement involved in inflammatory response wound healing
GO:3151; outflow tract morphogenesis
GO:3208; cardiac ventricle morphogenesis
GO:6089; lactate metabolic process
GO:6110; regulation of glycolytic process
GO:6879; cellular iron ion homeostasis
GO:7595; lactation
GO:8542; visual learning
GO:10508; positive regulation of autophagy
GO:10634; positive regulation of epithelial cell migration
GO:14850; response to muscle activity
GO:16239; positive regulation of macroautophagy
GO:21502; neural fold elevation formation
GO:21987; cerebral cortex development
GO:30154; cell differentiation
GO:30279; negative regulation of ossification
GO:30502; negative regulation of bone mineralization
GO:30949; positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:32007; negative regulation of TOR signaling
GO:32364; oxygen homeostasis
GO:32963; collagen metabolic process
GO:35162; embryonic hemopoiesis
GO:35774; positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:42127; regulation of cell population proliferation
GO:42541; hemoglobin biosynthetic process
GO:42593; glucose homeostasis
GO:43066; negative regulation of apoptotic process
GO:43524; negative regulation of neuron apoptotic process
GO:43619; regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:45648; positive regulation of erythrocyte differentiation
GO:45926; negative regulation of growth
GO:46716; muscle cell cellular homeostasis
GO:48514; blood vessel morphogenesis
GO:48546; digestive tract morphogenesis
GO:48593; camera-type eye morphogenesis
GO:50790; regulation of catalytic activity
GO:51216; cartilage development
GO:51541; elastin metabolic process
GO:60574; intestinal epithelial cell maturation
GO:61030; epithelial cell differentiation involved in mammary gland alveolus development
GO:61072; iris morphogenesis
GO:61298; retina vasculature development in camera-type eye
GO:70243; regulation of thymocyte apoptotic process
GO:70244; negative regulation of thymocyte apoptotic process
GO:71456; cellular response to hypoxia
GO:71542; dopaminergic neuron differentiation
GO:97411; hypoxia-inducible factor-1alpha signaling pathway
GO:1903599; positive regulation of autophagy of mitochondrion
GO:1903715; regulation of aerobic respiration
GO:2000378; negative regulation of reactive oxygen species metabolic process
GO:2001054; negative regulation of mesenchymal cell apoptotic process
GO:1938; positive regulation of endothelial cell proliferation
GO:32722; positive regulation of chemokine production
GO:45766; positive regulation of angiogenesis
GO:1678; cellular glucose homeostasis
GO:10629; negative regulation of gene expression
GO:51000; positive regulation of nitric-oxide synthase activity
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:10573; vascular endothelial growth factor production
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:1903377; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:19896; axonal transport of mitochondrion
GO:7165; signal transduction
GO:2000273; positive regulation of signaling receptor activity
GO:10575; positive regulation of vascular endothelial growth factor production
GO:45821; positive regulation of glycolytic process
GO:302; response to reactive oxygen species
GO:70101; positive regulation of chemokine-mediated signaling pathway
GO:10039; response to iron ion
GO:71347; cellular response to interleukin-1
GO:61419; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:46886; positive regulation of hormone biosynthetic process
GO:1900017; positive regulation of cytokine production involved in inflammatory response
GO:32909; regulation of transforming growth factor beta2 production
GO:2000434; regulation of protein neddylation

Cellular component:

GO:5737; cytoplasm
GO:5634; nucleus
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:5829; cytosol
GO:1904115; axon cytoplasm
GO:16604; nuclear body
GO:785; chromatin
GO:31514; motile cilium
GO:32991; protein-containing complex
GO:5667; transcription regulator complex
GO:90575; RNA polymerase II transcription regulator complex

Function:

GO:5515; protein binding
GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:31625; ubiquitin protein ligase binding
GO:3700; DNA-binding transcription factor activity
GO:19899; enzyme binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:19901; protein kinase binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:42826; histone deacetylase binding
GO:43565; sequence-specific DNA binding
GO:46982; protein heterodimerization activity
GO:70888; E-box binding
GO:19904; protein domain specific binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:51879; Hsp90 protein binding
GO:2039; p53 binding
GO:16922; nuclear receptor binding
GO:1223; transcription coactivator binding
GO:1216; DNA-binding transcription activator activity

Hide GO terms

Danio rerio

hif1ab

Mus musculus

Hif1a

Rattus norvegicus

Hif1a

GenAge human genes