Cell Senescence Entries for HIVEP1

Cell Types
Foreskin fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Ghosh et al. (2008) Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence. PLoS One 3(10)e3384 (PubMed)

HIVEP1 Gene Information

HGNC symbol
HIVEP1 
Aliases
CIRIP; CRYBP1; MBP-1; PRDII-BF1; Schnurri-1; ZAS1; ZNF40; ZNF40A 
Common name
HIVEP zinc finger 1 
Entrez Id
3096
Description
This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011].

HIVEP1 Ontologies

Gene Ontology
Process: GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:30509; BMP signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:16604; nuclear body
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
Hide GO terms

Homologs of HIVEP1 in Model Organisms

Danio rerio
hivep1
Drosophila melanogaster
shn
Mus musculus
Hivep1
Rattus norvegicus
Hivep1

External links

OMIM
194540
Ensembl
ENSG00000095951
Entrez Gene
3096
UniGene
567284
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HIVEP1
GeneCards
HIVEP1