Cell Senescence Entries for HMGA1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Narita et al. (2006) A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126(3)503-14 (PubMed)

HMGA1 Gene Information

HGNC symbol
HMGA1 
Aliases
HMGIY 
Common name
high mobility group AT-hook 1 
Entrez Id
3159
Description
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016].

HMGA1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:8285; negative regulation of cell population proliferation
GO:6284; base-excision repair
GO:6268; DNA unwinding involved in DNA replication
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6337; nucleosome disassembly
GO:90402; oncogene-induced cell senescence
Cellular component: GO:5634; nucleus
GO:5925; focal adhesion
GO:5694; chromosome
GO:785; chromatin
GO:5654; nucleoplasm
GO:5829; cytosol
GO:90575; RNA polymerase II transcription regulator complex
GO:5667; transcription regulator complex
GO:35985; senescence-associated heterochromatin focus
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:30374; nuclear receptor coactivator activity
GO:19899; enzyme binding
GO:3906; DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:3712; transcription coregulator activity
GO:42974; retinoic acid receptor binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3713; transcription coactivator activity
GO:1221; transcription coregulator binding
GO:3682; chromatin binding
GO:42975; peroxisome proliferator activated receptor binding
GO:46965; retinoid X receptor binding
GO:51575; 5'-deoxyribose-5-phosphate lyase activity
GO:987; cis-regulatory region sequence-specific DNA binding
GO:3680; minor groove of adenine-thymine-rich DNA binding
GO:30527; structural constituent of chromatin
Hide GO terms

Homologs of HMGA1 in Model Organisms

Danio rerio
hmga1b
Mus musculus
Hmga1
Rattus norvegicus
Hmga1

In other databases

CellAge gene expression
  • This gene is present as HMGA1

External links

OMIM
600701
Ensembl
ENSG00000137309
Entrez Gene
3159
UniGene
696527
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HMGA1
GeneCards
HMGA1