Cell Senescence Entries for HMGA2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Narita et al. (2006) A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126(3)503-14 (PubMed)

HMGA2 Gene Information

HGNC symbol
HMGA2 
Aliases
BABL; HMGIC; LIPO 
Common name
high mobility group AT-hook 2 
Entrez Id
8091
Description
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

HMGA2 Ontologies

Gene Ontology
Process: GO:2000773; negative regulation of cellular senescence
GO:7049; cell cycle
GO:43066; negative regulation of apoptotic process
GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:51301; cell division
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30261; chromosome condensation
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:43065; positive regulation of apoptotic process
GO:40008; regulation of growth
GO:2000036; regulation of stem cell population maintenance
GO:6284; base-excision repair
GO:45444; fat cell differentiation
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:10628; positive regulation of gene expression
GO:9615; response to virus
GO:48863; stem cell differentiation
GO:45766; positive regulation of angiogenesis
GO:7095; mitotic G2 DNA damage checkpoint signaling
GO:2062; chondrocyte differentiation
GO:31507; heterochromatin assembly
GO:1837; epithelial to mesenchymal transition
GO:2001022; positive regulation of response to DNA damage stimulus
GO:35987; endodermal cell differentiation
GO:48333; mesodermal cell differentiation
GO:43392; negative regulation of DNA binding
GO:43922; negative regulation by host of viral transcription
GO:2000648; positive regulation of stem cell proliferation
GO:48762; mesenchymal cell differentiation
GO:90402; oncogene-induced cell senescence
GO:35988; chondrocyte proliferation
GO:71864; positive regulation of cell proliferation in bone marrow
GO:10564; regulation of cell cycle process
GO:3131; mesodermal-endodermal cell signaling
GO:31052; chromosome breakage
GO:35978; histone H2A-S139 phosphorylation
GO:45869; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:2000685; positive regulation of cellular response to X-ray
GO:2001033; negative regulation of double-strand break repair via nonhomologous end joining
Cellular component: GO:5634; nucleus
GO:785; chromatin
GO:228; nuclear chromosome
GO:5654; nucleoplasm
GO:32993; protein-DNA complex
GO:35985; senescence-associated heterochromatin focus
GO:71141; SMAD protein complex
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:976; transcription cis-regulatory region binding
GO:3714; transcription corepressor activity
GO:3906; DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:3712; transcription coregulator activity
GO:8301; DNA binding, bending
GO:31492; nucleosomal DNA binding
GO:51575; 5'-deoxyribose-5-phosphate lyase activity
GO:46332; SMAD binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:3680; minor groove of adenine-thymine-rich DNA binding
GO:70742; C2H2 zinc finger domain binding
GO:35497; cAMP response element binding
GO:35500; MH2 domain binding
GO:35501; MH1 domain binding
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Homologs of HMGA2 in Model Organisms

Danio rerio
hmga2
Mus musculus
Hmga2
Rattus norvegicus
Hmga2

In other databases

CellAge gene expression
  • This gene is present as HMGA2

External links

OMIM
600698
Ensembl
ENSG00000149948
Entrez Gene
8091
UniGene
666976
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HMGA2
GeneCards
HMGA2