The HMGB1 gene and its putative association with human ageing

Cell Types

Lung cancer, Melanoma

Cell Lines

A375, G361, NCI-H1299, SK-MEL-28

Cancer Cell?

Yes

Method

Knockdown

Type of senescence

Unclear

Senescence Effect

Inhibits

Primary Reference

Li et al. (2015) Overexpression of HMGB1 in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent pathway. Oncotarget 5(15)6387-403 (PubMed)

HGNC symbol

HMGB1

Aliases

DKFZp686A04236; HMG1; HMG3; SBP-1

Common name

high mobility group box 1

Entrez Id

3146

Description

This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015].

Gene Ontology

Process:

GO:7165; signal transduction
GO:6935; chemotaxis
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6914; autophagy
GO:6310; DNA recombination
GO:122; negative regulation of transcription by RNA polymerase II
GO:2376; immune system process
GO:45087; innate immune response
GO:43065; positive regulation of apoptotic process
GO:6954; inflammatory response
GO:51276; chromosome organization
GO:2250; adaptive immune response
GO:32392; DNA geometric change
GO:48584; positive regulation of response to stimulus
GO:6357; regulation of transcription by RNA polymerase II
GO:6265; DNA topological change
GO:10508; positive regulation of autophagy
GO:32733; positive regulation of interleukin-10 production
GO:32755; positive regulation of interleukin-6 production
GO:32760; positive regulation of tumor necrosis factor production
GO:43410; positive regulation of MAPK cascade
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:32689; negative regulation of interferon-gamma production
GO:32735; positive regulation of interleukin-12 production
GO:2001200; positive regulation of dendritic cell differentiation
GO:71222; cellular response to lipopolysaccharide
GO:6303; double-strand break repair via nonhomologous end joining
GO:7204; positive regulation of cytosolic calcium ion concentration
GO:43280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:43277; apoptotic cell clearance
GO:31175; neuron projection development
GO:2218; activation of innate immune response
GO:46330; positive regulation of JNK cascade
GO:50918; positive chemotaxis
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:1905564; positive regulation of vascular endothelial cell proliferation
GO:90026; positive regulation of monocyte chemotaxis
GO:43388; positive regulation of DNA binding
GO:42104; positive regulation of activated T cell proliferation
GO:2407; dendritic cell chemotaxis
GO:32757; positive regulation of interleukin-8 production
GO:2437; inflammatory response to antigenic stimulus
GO:32732; positive regulation of interleukin-1 production
GO:1773; myeloid dendritic cell activation
GO:2643; regulation of tolerance induction
GO:2840; regulation of T cell mediated immune response to tumor cell
GO:17055; negative regulation of RNA polymerase II transcription preinitiation complex assembly
GO:31507; heterochromatin assembly
GO:32072; regulation of restriction endodeoxyribonuclease activity
GO:32425; positive regulation of mismatch repair
GO:33151; V(D)J recombination
GO:34165; positive regulation of toll-like receptor 9 signaling pathway
GO:35711; T-helper 1 cell activation
GO:43371; negative regulation of CD4-positive, alpha-beta T cell differentiation
GO:43537; negative regulation of blood vessel endothelial cell migration
GO:45063; T-helper 1 cell differentiation
GO:51106; positive regulation of DNA ligation
GO:97350; neutrophil clearance
GO:2000343; positive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000426; negative regulation of apoptotic cell clearance

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5768; endosome
GO:5576; extracellular region
GO:5694; chromosome
GO:5615; extracellular space
GO:793; condensed chromosome
GO:9986; cell surface
GO:5793; endoplasmic reticulum-Golgi intermediate compartment
GO:5654; nucleoplasm
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
GO:17053; transcription repressor complex
GO:35868; alphav-beta3 integrin-HMGB1 complex

Function:

GO:3723; RNA binding
GO:3677; DNA binding
GO:16829; lyase activity
GO:5515; protein binding
GO:5125; cytokine activity
GO:3684; damaged DNA binding
GO:3713; transcription coactivator activity
GO:400; four-way junction DNA binding
GO:405; bubble DNA binding
GO:8301; DNA binding, bending
GO:97100; supercoiled DNA binding
GO:976; transcription cis-regulatory region binding
GO:140297; DNA-binding transcription factor binding
GO:3690; double-stranded DNA binding
GO:3697; single-stranded DNA binding
GO:1530; lipopolysaccharide binding
GO:1786; phosphatidylserine binding
GO:70182; DNA polymerase binding
GO:3714; transcription corepressor activity
GO:42056; chemoattractant activity
GO:5178; integrin binding
GO:50786; RAGE receptor binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:19958; C-X-C chemokine binding

Hide GO terms

Mus musculus

Hmgb1

Rattus norvegicus

LOC685520

GenAge human genes