Cell Senescence Entries for HMGB2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown, Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Aird et al. (2017) HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci. J Cell Biol 215(3)325-334 (PubMed)

HMGB2 Gene Information

HGNC symbol
HMGB2 
Aliases
HMG2 
Common name
high mobility group box 2 
Entrez Id
3148
Description
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008].

HMGB2 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:6334; nucleosome assembly
GO:6935; chemotaxis
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6310; DNA recombination
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:2376; immune system process
GO:45087; innate immune response
GO:6954; inflammatory response
GO:6357; regulation of transcription by RNA polymerase II
GO:32392; DNA geometric change
GO:6265; DNA topological change
GO:71222; cellular response to lipopolysaccharide
GO:45892; negative regulation of transcription, DNA-templated
GO:6303; double-strand break repair via nonhomologous end joining
GO:60326; cell chemotaxis
GO:50918; positive chemotaxis
GO:1938; positive regulation of endothelial cell proliferation
GO:43388; positive regulation of DNA binding
GO:45648; positive regulation of erythrocyte differentiation
GO:33151; V(D)J recombination
GO:45654; positive regulation of megakaryocyte differentiation
GO:2437; inflammatory response to antigenic stimulus
GO:7283; spermatogenesis
GO:7289; spermatid nucleus differentiation
GO:8584; male gonad development
GO:10628; positive regulation of gene expression
GO:10629; negative regulation of gene expression
GO:32075; positive regulation of nuclease activity
GO:32496; response to lipopolysaccharide
GO:32728; positive regulation of interferon-beta production
GO:45089; positive regulation of innate immune response
GO:48545; response to steroid hormone
GO:50767; regulation of neurogenesis
GO:50829; defense response to Gram-negative bacterium
GO:50830; defense response to Gram-positive bacterium
GO:72091; regulation of stem cell proliferation
GO:1902042; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5576; extracellular region
GO:5694; chromosome
GO:5615; extracellular space
GO:48471; perinuclear region of cytoplasm
GO:793; condensed chromosome
GO:785; chromatin
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:3677; DNA binding
GO:8134; transcription factor binding
GO:3684; damaged DNA binding
GO:3713; transcription coactivator activity
GO:400; four-way junction DNA binding
GO:97100; supercoiled DNA binding
GO:976; transcription cis-regulatory region binding
GO:3690; double-stranded DNA binding
GO:8301; DNA binding, bending
GO:987; cis-regulatory region sequence-specific DNA binding
GO:3697; single-stranded DNA binding
GO:42056; chemoattractant activity
GO:50786; RAGE receptor binding
GO:19904; protein domain specific binding
GO:44378; non-sequence-specific DNA binding, bending
GO:140297; DNA-binding transcription factor binding
Hide GO terms

Homologs of HMGB2 in Model Organisms

Danio rerio
hmgb2a
Mus musculus
Hmgb2
Rattus norvegicus
Hmgb2

In other databases

GenAge human genes
  • This gene is present as HMGB2
CellAge gene expression
  • This gene is present as HMGB2

External links

OMIM
163906
Ensembl
ENSG00000164104
Entrez Gene
3148
UniGene
434953
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HMGB2
GeneCards
HMGB2