Cell Senescence Entries for HMGB3

Cell Types
Gastric cancer
Cell Lines
BGC-823, MGC-803
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Guo et al. (2017) Knockdown of High Mobility Group-Box 3 (HMGB3) Expression Inhibits Proliferation, Reduces Migration, and Affects Chemosensitivity in Gastric Cancer Cells. Med Sci Monit 22(2)3951-3960 (PubMed)

HMGB3 Gene Information

HGNC symbol
HMGB3 
Aliases
HMG2A; HMG4; MGC90319 
Common name
high mobility group box 3 
Entrez Id
3149
Description
This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

HMGB3 Ontologies

Gene Ontology
Process: GO:2376; immune system process
GO:45087; innate immune response
GO:6310; DNA recombination
GO:32392; DNA geometric change
GO:6357; regulation of transcription by RNA polymerase II
GO:45578; negative regulation of B cell differentiation
GO:45638; negative regulation of myeloid cell differentiation
Cellular component: GO:5634; nucleus
GO:5694; chromosome
GO:5737; cytoplasm
Function: GO:3677; DNA binding
GO:3723; RNA binding
GO:5515; protein binding
GO:400; four-way junction DNA binding
GO:8301; DNA binding, bending
GO:3690; double-stranded DNA binding
Hide GO terms

Homologs of HMGB3 in Model Organisms

Drosophila melanogaster
Dsp1
Mus musculus
Gm6104
Rattus norvegicus
Hmgb3

In other databases

CellAge gene expression
  • This gene is present as HMGB3

External links

OMIM
300193
Ensembl
ENSG00000029993
Entrez Gene
3149
UniGene
19114
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HMGB3
GeneCards
HMGB3