Cell Senescence Entries for HMGCR

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Efimova et al. (2019) HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation. Mol Cancer Ther 17(2)407-418 (PubMed)

HMGCR Gene Information

HGNC symbol
HMGCR 
Aliases
 
Common name
3-hydroxy-3-methylglutaryl-CoA reductase 
Entrez Id
3156
Description
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

HMGCR Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:6694; steroid biosynthetic process
GO:6695; cholesterol biosynthetic process
GO:8202; steroid metabolic process
GO:8203; cholesterol metabolic process
GO:8299; isoprenoid biosynthetic process
GO:16126; sterol biosynthetic process
GO:15936; coenzyme A metabolic process
GO:1900222; negative regulation of amyloid-beta clearance
GO:42177; negative regulation of protein catabolic process
GO:50709; negative regulation of protein secretion
GO:8542; visual learning
GO:43407; negative regulation of MAP kinase activity
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5777; peroxisome
GO:5778; peroxisomal membrane
Function: GO:16491; oxidoreductase activity
GO:50661; NADP binding
GO:16616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:5515; protein binding
GO:4420; hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:70402; NADPH binding
GO:120225; coenzyme A binding
Hide GO terms

Homologs of HMGCR in Model Organisms

Caenorhabditis elegans
hmgr-1
Danio rerio
hmgcra
Drosophila melanogaster
Hmgcr
Mus musculus
Hmgcr
Rattus norvegicus
Hmgcr
Saccharomyces cerevisiae
HMG2
Schizosaccharomyces pombe
hmg1

External links

OMIM
142910
Ensembl
ENSG00000113161
Entrez Gene
3156
UniGene
643495
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HMGCR
GeneCards
HMGCR