Cell Senescence Entries for HNRNPAB

Cell Types
Mammary fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Avelar et al. (2021) A multidimensional systems biology analysis of cellular senescence in aging and disease. Genome Biol 21(1)91 (PubMed)

HNRNPAB Gene Information

HGNC symbol
HNRNPAB 
Aliases
ABBP1; FLJ40338; HNRPAB 
Common name
heterogeneous nuclear ribonucleoprotein A/B 
Entrez Id
3182
Description
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

HNRNPAB Ontologies

Gene Ontology
Process: GO:10468; regulation of gene expression
GO:45893; positive regulation of transcription, DNA-templated
GO:16556; mRNA modification
GO:2000623; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:1837; epithelial to mesenchymal transition
GO:60341; regulation of cellular localization
GO:71230; cellular response to amino acid stimulus
GO:1904580; regulation of intracellular mRNA localization
GO:1901537; positive regulation of DNA demethylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:1990904; ribonucleoprotein complex
GO:90575; RNA polymerase II transcription regulator complex
GO:30425; dendrite
GO:71598; neuronal ribonucleoprotein granule
GO:1990124; messenger ribonucleoprotein complex
GO:45293; mRNA editing complex
GO:110165; cellular anatomical entity
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:5515; protein binding
GO:3729; mRNA binding
GO:44877; protein-containing complex binding
GO:1990837; sequence-specific double-stranded DNA binding
Hide GO terms

Homologs of HNRNPAB in Model Organisms

Danio rerio
zgc:77052
Drosophila melanogaster
sqd
Mus musculus
Hnrnpab
Rattus norvegicus
Hnrnpab

In other databases

CellAge gene expression

External links

OMIM
602688
Ensembl
ENSG00000197451
Entrez Gene
3182
UniGene
715055
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HNRNPAB
GeneCards
HNRNPAB