Cell Senescence Entries for HNRNPD

Cell Types
Aortic endothelial, Breast cancer
Cell Lines
MDA-MB-231, Primary cell
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Al-Khalaf et al. (2017) p16INK4A induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1. Mol Carcinog 56(3)985-999 (PubMed)

HNRNPD Gene Information

HGNC symbol
HNRNPD 
Aliases
AUF1; HNRPD 
Common name
heterogeneous nuclear ribonucleoprotein D 
Entrez Id
3184
Description
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008].

HNRNPD Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:48511; rhythmic process
GO:10468; regulation of gene expression
GO:1889; liver development
GO:7420; brain development
GO:10628; positive regulation of gene expression
GO:10629; negative regulation of gene expression
GO:21549; cerebellum development
GO:32204; regulation of telomere maintenance
GO:32355; response to estradiol
GO:43488; regulation of mRNA stability
GO:48255; mRNA stabilization
GO:51592; response to calcium ion
GO:51602; response to electrical stimulus
GO:61158; 3'-UTR-mediated mRNA destabilization
GO:71230; cellular response to amino acid stimulus
GO:71392; cellular response to estradiol stimulus
GO:71732; cellular response to nitric oxide
GO:1901355; response to rapamycin
GO:1904355; positive regulation of telomere capping
GO:1904383; response to sodium phosphate
GO:1904586; cellular response to putrescine
GO:1905663; positive regulation of telomerase RNA reverse transcriptase activity
GO:1990828; hepatocyte dedifferentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45727; positive regulation of translation
GO:6401; RNA catabolic process
GO:42752; regulation of circadian rhythm
GO:97167; circadian regulation of translation
GO:6396; RNA processing
GO:70934; CRD-mediated mRNA stabilization
GO:1900152; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000767; positive regulation of cytoplasmic translation
GO:42789; mRNA transcription by RNA polymerase II
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:110165; cellular anatomical entity
GO:5654; nucleoplasm
GO:1990904; ribonucleoprotein complex
GO:5829; cytosol
GO:45202; synapse
GO:106002; mCRD-mediated mRNA stability complex
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:3677; DNA binding
GO:5515; protein binding
GO:3680; minor groove of adenine-thymine-rich DNA binding
GO:3682; chromatin binding
GO:3729; mRNA binding
GO:35925; mRNA 3'-UTR AU-rich region binding
GO:42826; histone deacetylase binding
GO:42162; telomeric DNA binding
Hide GO terms

Homologs of HNRNPD in Model Organisms

Danio rerio
hnrnpd
Mus musculus
Hnrnpd
Rattus norvegicus
Hnrnpd

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Hnrnpd
CellAge gene expression
  • This gene is present as HNRNPD

External links

OMIM
601324
Ensembl
ENSG00000138668
Entrez Gene
3184
UniGene
480073
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HNRNPD
GeneCards
HNRNPD