Cell Senescence Entries for HOPX

Cell Types
Bronchial epithelial
Cell Lines
HBEC, Y-BE
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Chen et al. (2015) HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer. J Pathol 235(3)397-407 (PubMed)

HOPX Gene Information

HGNC symbol
HOPX 
Aliases
HOP; LAGY; NECC1; OB1; SMAP31 
Common name
HOP homeobox 
Entrez Id
84525
Description
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009].

HOPX Ontologies

Gene Ontology
Process: GO:30154; cell differentiation
GO:6357; regulation of transcription by RNA polymerase II
GO:51131; chaperone-mediated protein complex assembly
GO:1829; trophectodermal cell differentiation
GO:3166; bundle of His development
GO:45596; negative regulation of cell differentiation
GO:122; negative regulation of transcription by RNA polymerase II
GO:7507; heart development
GO:8016; regulation of heart contraction
GO:16575; histone deacetylation
GO:43393; regulation of protein binding
GO:43415; positive regulation of skeletal muscle tissue regeneration
GO:48286; lung alveolus development
GO:51155; positive regulation of striated muscle cell differentiation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:785; chromatin
Function: GO:3677; DNA binding
GO:5515; protein binding
Hide GO terms

Homologs of HOPX in Model Organisms

Danio rerio
hopx
Mus musculus
Hopx
Rattus norvegicus
Hopx

External links

OMIM
607275
Ensembl
ENSG00000171476
Entrez Gene
84525
UniGene
619396
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HOPX
GeneCards
HOPX