Cell Senescence Entries for HRAS

Cell Types
Lung fibroblast
Cell Lines
IMR-90, WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Serrano et al. (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88(5)593-602 (PubMed)

HRAS Gene Information

HGNC symbol
HRAS 
Aliases
HRAS1 
Common name
HRas proto-oncogene, GTPase 
Entrez Id
3265
Description
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008].

HRAS Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:90314; positive regulation of protein targeting to membrane
GO:8284; positive regulation of cell population proliferation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:2000251; positive regulation of actin cytoskeleton reorganization
GO:6935; chemotaxis
GO:30335; positive regulation of cell migration
GO:43547; positive regulation of GTPase activity
GO:43406; positive regulation of MAP kinase activity
GO:7166; cell surface receptor signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:46330; positive regulation of JNK cascade
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:1934; positive regulation of protein phosphorylation
GO:9887; animal organ morphogenesis
GO:10629; negative regulation of gene expression
GO:7265; Ras protein signal transduction
GO:8285; negative regulation of cell population proliferation
GO:165; MAPK cascade
GO:51726; regulation of cell cycle
GO:10863; positive regulation of phospholipase C activity
GO:34260; negative regulation of GTPase activity
GO:42127; regulation of cell population proliferation
GO:43405; regulation of MAP kinase activity
GO:43410; positive regulation of MAPK cascade
GO:50679; positive regulation of epithelial cell proliferation
GO:71480; cellular response to gamma radiation
GO:90303; positive regulation of wound healing
GO:90398; cellular senescence
GO:98696; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:1900029; positive regulation of ruffle assembly
GO:2000630; positive regulation of miRNA metabolic process
GO:6897; endocytosis
GO:7264; small GTPase mediated signal transduction
GO:7569; cell aging
GO:10628; positive regulation of gene expression
GO:32729; positive regulation of interferon-gamma production
GO:42088; T-helper 1 type immune response
GO:42832; defense response to protozoan
GO:43524; negative regulation of neuron apoptotic process
GO:48169; regulation of long-term neuronal synaptic plasticity
GO:50852; T cell receptor signaling pathway
GO:60612; adipose tissue development
GO:97193; intrinsic apoptotic signaling pathway
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:139; Golgi membrane
GO:48471; perinuclear region of cytoplasm
GO:5789; endoplasmic reticulum membrane
GO:98978; glutamatergic synapse
GO:1905360; GTPase complex
Function: GO:166; nucleotide binding
GO:16787; hydrolase activity
GO:3924; GTPase activity
GO:5525; GTP binding
GO:3925; G protein activity
GO:5515; protein binding
GO:8022; protein C-terminus binding
GO:19003; GDP binding
Hide GO terms

Homologs of HRAS in Model Organisms

Danio rerio
hrasb
Mus musculus
Hras1
Rattus norvegicus
Hras1

In other databases

GenAge human genes
  • This gene is present as HRAS
LongevityMap
  • This gene is present as HRAS

External links

OMIM
190020
Ensembl
ENSG00000174775
Entrez Gene
3265
UniGene
37003
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HRAS
GeneCards
HRAS