Cell Senescence Entries for HSP90AA1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
IMR-90, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Han et al. (2017) Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF. Cancer Res 77(2)343-354 (PubMed)

HSP90AA1 Gene Information

HGNC symbol
HSP90AA1 
Aliases
FLJ31884; Hsp89; Hsp90; HSP90N; HSPC1; HSPCA 
Common name
heat shock protein 90 alpha family class A member 1 
Entrez Id
3320
Description
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

HSP90AA1 Ontologies

Gene Ontology
Process: GO:7004; telomere maintenance via telomerase
GO:50790; regulation of catalytic activity
GO:6457; protein folding
GO:6986; response to unfolded protein
GO:9409; response to cold
GO:9408; response to heat
GO:42981; regulation of apoptotic process
GO:50821; protein stabilization
GO:98586; cellular response to virus
GO:46677; response to antibiotic
GO:32728; positive regulation of interferon-beta production
GO:51973; positive regulation of telomerase activity
GO:2218; activation of innate immune response
GO:2230; positive regulation of defense response to virus by host
GO:1934; positive regulation of protein phosphorylation
GO:42026; protein refolding
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:51897; positive regulation of protein kinase B signaling
GO:6839; mitochondrial transport
GO:1902949; positive regulation of tau-protein kinase activity
GO:21955; central nervous system neuron axonogenesis
GO:30010; establishment of cell polarity
GO:31396; regulation of protein ubiquitination
GO:32273; positive regulation of protein polymerization
GO:32880; regulation of protein localization
GO:34605; cellular response to heat
GO:43254; regulation of protein-containing complex assembly
GO:43335; protein unfolding
GO:45040; protein insertion into mitochondrial outer membrane
GO:45429; positive regulation of nitric oxide biosynthetic process
GO:48675; axon extension
GO:51131; chaperone-mediated protein complex assembly
GO:61684; chaperone-mediated autophagy
GO:1903364; positive regulation of cellular protein catabolic process
GO:1905323; telomerase holoenzyme complex assembly
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:32991; protein-containing complex
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5829; cytosol
GO:42470; melanosome
GO:5576; extracellular region
GO:5654; nucleoplasm
GO:70062; extracellular exosome
GO:43025; neuronal cell body
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
GO:48471; perinuclear region of cytoplasm
GO:44295; axonal growth cone
GO:71682; endocytic vesicle lumen
GO:43209; myelin sheath
GO:43202; lysosomal lumen
GO:44294; dendritic growth cone
Function: GO:5515; protein binding
GO:70182; DNA polymerase binding
GO:3723; RNA binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:16787; hydrolase activity
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:16887; ATP hydrolysis activity
GO:51082; unfolded protein binding
GO:19899; enzyme binding
GO:30911; TPR domain binding
GO:48156; tau protein binding
GO:42826; histone deacetylase binding
GO:97110; scaffold protein binding
GO:1990782; protein tyrosine kinase binding
GO:51020; GTPase binding
GO:97718; disordered domain specific binding
GO:30235; nitric-oxide synthase regulator activity
GO:23026; MHC class II protein complex binding
GO:31625; ubiquitin protein ligase binding
Hide GO terms

Homologs of HSP90AA1 in Model Organisms

Caenorhabditis elegans
daf-21
Danio rerio
hsp90aa1.2
Mus musculus
Hsp90aa1
Rattus norvegicus
Hsp90aa1

In other databases

GenAge human genes

External links

OMIM
140571
Ensembl
ENSG00000080824
Entrez Gene
3320
UniGene
525600
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HSP90AA1
GeneCards
HSP90AA1