The HSP90AB1 gene and its putative association with human ageing

Cell Types

Foreskin fibroblast, Lung fibroblast

Cell Lines

IMR-90, Primary cell

Cancer Cell?

No

Method

Knockdown

Type of senescence

Oncogene-induced

Senescence Effect

Inhibits

Primary Reference

Han et al. (2017) Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF. Cancer Res 77(2)343-354 (PubMed)

HGNC symbol

HSP90AB1

Aliases

HSPC2; HSPCB

Common name

heat shock protein 90 alpha family class B member 1

Entrez Id

3326

Description

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012].

Gene Ontology

Process:

GO:7004; telomere maintenance via telomerase
GO:6457; protein folding
GO:6986; response to unfolded protein
GO:51726; regulation of cell cycle
GO:1890; placenta development
GO:9410; response to xenobiotic stimulus
GO:9651; response to salt stress
GO:10033; response to organic substance
GO:21955; central nervous system neuron axonogenesis
GO:30010; establishment of cell polarity
GO:32092; positive regulation of protein binding
GO:32880; regulation of protein localization
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:34605; cellular response to heat
GO:42220; response to cocaine
GO:42307; positive regulation of protein import into nucleus
GO:43066; negative regulation of apoptotic process
GO:43524; negative regulation of neuron apoptotic process
GO:45793; positive regulation of cell size
GO:48675; axon extension
GO:51248; negative regulation of protein metabolic process
GO:51897; positive regulation of protein kinase B signaling
GO:71353; cellular response to interleukin-4
GO:71407; cellular response to organic cyclic compound
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:1901799; negative regulation of proteasomal protein catabolic process
GO:1903660; negative regulation of complement-dependent cytotoxicity
GO:1904031; positive regulation of cyclin-dependent protein kinase activity
GO:32435; negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:30511; positive regulation of transforming growth factor beta receptor signaling pathway
GO:51973; positive regulation of telomerase activity
GO:2000010; positive regulation of protein localization to cell surface
GO:1902949; positive regulation of tau-protein kinase activity
GO:50821; protein stabilization
GO:31396; regulation of protein ubiquitination
GO:45429; positive regulation of nitric oxide biosynthetic process
GO:1905323; telomerase holoenzyme complex assembly
GO:19062; virion attachment to host cell
GO:32516; positive regulation of phosphoprotein phosphatase activity
GO:45597; positive regulation of cell differentiation
GO:51131; chaperone-mediated protein complex assembly
GO:97435; supramolecular fiber organization
GO:1901389; negative regulation of transforming growth factor beta activation

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:32991; protein-containing complex
GO:5829; cytosol
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5576; extracellular region
GO:42470; melanosome
GO:8180; COP9 signalosome
GO:5765; lysosomal membrane
GO:9986; cell surface
GO:16234; inclusion body
GO:16323; basolateral plasma membrane
GO:16324; apical plasma membrane
GO:31526; brush border membrane
GO:43025; neuronal cell body
GO:44294; dendritic growth cone
GO:44295; axonal growth cone
GO:48471; perinuclear region of cytoplasm
GO:1990565; HSP90-CDC37 chaperone complex
GO:1990913; sperm head plasma membrane
GO:1990917; ooplasm
GO:120293; dynein axonemal particle
GO:5654; nucleoplasm
GO:70062; extracellular exosome
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
GO:34751; aryl hydrocarbon receptor complex

Function:

GO:70182; DNA polymerase binding
GO:3723; RNA binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:5515; protein binding
GO:16887; ATP hydrolysis activity
GO:46983; protein dimerization activity
GO:51082; unfolded protein binding
GO:2134; UTP binding
GO:2135; CTP binding
GO:5525; GTP binding
GO:17098; sulfonylurea receptor binding
GO:19887; protein kinase regulator activity
GO:19899; enzyme binding
GO:19900; kinase binding
GO:19901; protein kinase binding
GO:32564; dATP binding
GO:44183; protein folding chaperone
GO:44325; transmembrane transporter binding
GO:48156; tau protein binding
GO:1901363; heterocyclic compound binding
GO:42802; identical protein binding
GO:45296; cadherin binding
GO:30911; TPR domain binding
GO:1990226; histone methyltransferase binding
GO:42277; peptide binding
GO:42826; histone deacetylase binding
GO:3725; double-stranded RNA binding
GO:31072; heat shock protein binding
GO:97718; disordered domain specific binding
GO:30235; nitric-oxide synthase regulator activity
GO:23026; MHC class II protein complex binding
GO:42803; protein homodimerization activity
GO:31625; ubiquitin protein ligase binding
GO:43008; ATP-dependent protein binding

Hide GO terms

Danio rerio

hsp90ab1

Drosophila melanogaster

Mus musculus

Rattus norvegicus

OMIM

Ensembl