Cell Senescence Entries for HSPB1

Cell Types
Mammary epithelial
Cell Lines
MCF-10A
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
O'Callaghan-Sunol et al. (2008) Hsp27 modulates p53 signaling and suppresses cellular senescence. Cancer Res 67(24)11779-88 (PubMed)

HSPB1 Gene Information

HGNC symbol
HSPB1 
Aliases
CMT2F; Hs.76067; Hsp25; HSP27; HSP28 
Common name
heat shock protein family B (small) member 1 
Entrez Id
3315
Description
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017].

HSPB1 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6986; response to unfolded protein
GO:1895; retina homeostasis
GO:9615; response to virus
GO:70527; platelet aggregation
GO:99641; anterograde axonal protein transport
GO:32760; positive regulation of tumor necrosis factor production
GO:45766; positive regulation of angiogenesis
GO:61077; chaperone-mediated protein folding
GO:6469; negative regulation of protein kinase activity
GO:35924; cellular response to vascular endothelial growth factor stimulus
GO:1932; regulation of protein phosphorylation
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:6446; regulation of translational initiation
GO:35556; intracellular signal transduction
GO:1902176; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:43122; regulation of I-kappaB kinase/NF-kappaB signaling
GO:10506; regulation of autophagy
GO:32731; positive regulation of interleukin-1 beta production
GO:38033; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:2001028; positive regulation of endothelial cell chemotaxis
GO:2001234; negative regulation of apoptotic signaling pathway
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5615; extracellular space
GO:1904115; axon cytoplasm
GO:5819; spindle
GO:5829; cytosol
GO:70062; extracellular exosome
GO:502; proteasome complex
GO:1533; cornified envelope
GO:5886; plasma membrane
GO:30018; Z disc
GO:43292; contractile fiber
Function: GO:3723; RNA binding
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:44183; protein folding chaperone
GO:19901; protein kinase binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:43130; ubiquitin binding
GO:5080; protein kinase C binding
GO:8426; protein kinase C inhibitor activity
Hide GO terms

Homologs of HSPB1 in Model Organisms

Danio rerio
hspb1
Mus musculus
Hspb1
Rattus norvegicus
Hspb1

External links

OMIM
602195
Ensembl
ENSG00000106211
Entrez Gene
3315
UniGene
520973
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HSPB1
GeneCards
HSPB1