Cell Senescence Entries for HTRA1

Cell Types
Retinal pigment epithelial
Cell Lines
ARPE-19
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Supanji et al. (2013) HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway. Exp Eye Res 112(2)79-92 (PubMed)

HTRA1 Gene Information

HGNC symbol
HTRA1 
Aliases
ARMD7; HtrA; IGFBP5-protease; PRSS11 
Common name
HtrA serine peptidase 1 
Entrez Id
5654
Description
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008].

HTRA1 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:43065; positive regulation of apoptotic process
GO:12501; programmed cell death
GO:1890; placenta development
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:30514; negative regulation of BMP signaling pathway
GO:50679; positive regulation of epithelial cell proliferation
GO:50687; negative regulation of defense response to virus
GO:60718; chorionic trophoblast cell differentiation
GO:97187; dentinogenesis
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5576; extracellular region
GO:5829; cytosol
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:5615; extracellular space
Function: GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:4252; serine-type endopeptidase activity
GO:5515; protein binding
GO:19838; growth factor binding
GO:8236; serine-type peptidase activity
GO:42802; identical protein binding
Hide GO terms

Homologs of HTRA1 in Model Organisms

Danio rerio
htra1a
Drosophila melanogaster
HtrA2
Mus musculus
Htra1
Rattus norvegicus
Htra1

In other databases

CellAge gene expression
  • This gene is present as HTRA1

External links

OMIM
602194
Ensembl
ENSG00000166033
Entrez Gene
5654
UniGene
501280
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HTRA1
GeneCards
HTRA1