Cell Senescence Entries for ID1

Cell Types
Dermal endothelial, Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Tang et al. (2002) The helix-loop-helix protein id-1 delays onset of replicative senescence in human endothelial cells. Lab Invest 82(8)1073-9 (PubMed)

ID1 Gene Information

HGNC symbol
ID1 
Aliases
bHLHb24; dJ857M17.1.2 
Common name
inhibitor of DNA binding 1, HLH protein 
Entrez Id
3397
Description
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

ID1 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:48511; rhythmic process
GO:122; negative regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:120163; negative regulation of cold-induced thermogenesis
GO:32922; circadian regulation of gene expression
GO:1525; angiogenesis
GO:7179; transforming growth factor beta receptor signaling pathway
GO:48514; blood vessel morphogenesis
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:10621; negative regulation of transcription by transcription factor localization
GO:43534; blood vessel endothelial cell migration
GO:7420; brain development
GO:10628; positive regulation of gene expression
GO:14070; response to organic cyclic compound
GO:30182; neuron differentiation
GO:32091; negative regulation of protein binding
GO:32233; positive regulation of actin filament bundle assembly
GO:36164; cell-abiotic substrate adhesion
GO:43066; negative regulation of apoptotic process
GO:43392; negative regulation of DNA binding
GO:45602; negative regulation of endothelial cell differentiation
GO:50679; positive regulation of epithelial cell proliferation
GO:50774; negative regulation of dendrite morphogenesis
GO:71364; cellular response to epidermal growth factor stimulus
GO:71560; cellular response to transforming growth factor beta stimulus
GO:1901342; regulation of vasculature development
GO:1901653; cellular response to peptide
GO:1903351; cellular response to dopamine
GO:1990090; cellular response to nerve growth factor stimulus
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5813; centrosome
Function: GO:46983; protein dimerization activity
GO:5515; protein binding
GO:140416; transcription regulator inhibitor activity
GO:8022; protein C-terminus binding
GO:42802; identical protein binding
GO:47485; protein N-terminus binding
GO:70628; proteasome binding
Hide GO terms

Homologs of ID1 in Model Organisms

Danio rerio
id1
Mus musculus
Id1
Rattus norvegicus
Id1

External links

OMIM
600349
Ensembl
ENSG00000125968
Entrez Gene
3397
UniGene
504609
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ID1
GeneCards
ID1