Cell Senescence Entries for IFI16

Cell Types
Prostate cancer
Cell Lines
PC-3
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Xin et al. (2003) Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. Oncogene 22(31)4831-40 (PubMed)

IFI16 Gene Information

HGNC symbol
IFI16 
Aliases
IFNGIP1; PYHIN2 
Common name
interferon gamma inducible protein 16 
Entrez Id
3428
Description
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011].

IFI16 Ontologies

Gene Ontology
Process: GO:2218; activation of innate immune response
GO:35458; cellular response to interferon-beta
GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6914; autophagy
GO:122; negative regulation of transcription by RNA polymerase II
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:6954; inflammatory response
GO:1819; positive regulation of cytokine production
GO:45071; negative regulation of viral genome replication
GO:32731; positive regulation of interleukin-1 beta production
GO:45824; negative regulation of innate immune response
GO:30224; monocyte differentiation
GO:10506; regulation of autophagy
GO:71479; cellular response to ionizing radiation
GO:42149; cellular response to glucose starvation
GO:72332; intrinsic apoptotic signaling pathway by p53 class mediator
GO:97202; activation of cysteine-type endopeptidase activity
GO:40029; regulation of gene expression, epigenetic
GO:42771; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:43392; negative regulation of DNA binding
GO:2000117; negative regulation of cysteine-type endopeptidase activity
GO:30099; myeloid cell differentiation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:16607; nuclear speck
Function: GO:3723; RNA binding
GO:3677; DNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:8134; transcription factor binding
GO:3690; double-stranded DNA binding
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Homologs of IFI16 in Model Organisms

Mus musculus
Ifi205a
Rattus norvegicus
Ifi204

External links

OMIM
147586
Ensembl
ENSG00000163565
Entrez Gene
3428
UniGene
380250
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IFI16
GeneCards
IFI16