Cell Senescence Entries for IFNG

Cell Types
Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Kim et al. (2009) Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells. Mech Ageing Dev 130(3)179-88 (PubMed)

IFNG Gene Information

HGNC symbol
IFNG 
Aliases
 
Common name
interferon gamma 
Entrez Id
3458
Description
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015].

IFNG Ontologies

Gene Ontology
Process: GO:50729; positive regulation of inflammatory response
GO:10629; negative regulation of gene expression
GO:7165; signal transduction
GO:51607; defense response to virus
GO:6955; immune response
GO:40008; regulation of growth
GO:10508; positive regulation of autophagy
GO:10628; positive regulation of gene expression
GO:8284; positive regulation of cell population proliferation
GO:32735; positive regulation of interleukin-12 production
GO:32834; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
GO:32700; negative regulation of interleukin-17 production
GO:32755; positive regulation of interleukin-6 production
GO:32760; positive regulation of tumor necrosis factor production
GO:7166; cell surface receptor signaling pathway
GO:122; negative regulation of transcription by RNA polymerase II
GO:6915; apoptotic process
GO:1903543; positive regulation of exosomal secretion
GO:45672; positive regulation of osteoclast differentiation
GO:97191; extrinsic apoptotic signaling pathway
GO:45429; positive regulation of nitric oxide biosynthetic process
GO:6959; humoral immune response
GO:51044; positive regulation of membrane protein ectodomain proteolysis
GO:32731; positive regulation of interleukin-1 beta production
GO:1901216; positive regulation of neuron death
GO:1774; microglial cell activation
GO:7259; receptor signaling pathway via JAK-STAT
GO:42531; positive regulation of tyrosine phosphorylation of STAT protein
GO:45348; positive regulation of MHC class II biosynthetic process
GO:51770; positive regulation of nitric-oxide synthase biosynthetic process
GO:2000273; positive regulation of signaling receptor activity
GO:1903078; positive regulation of protein localization to plasma membrane
GO:1902004; positive regulation of amyloid-beta formation
GO:2250; adaptive immune response
GO:1901857; positive regulation of cellular respiration
GO:48143; astrocyte activation
GO:50796; regulation of insulin secretion
GO:51173; positive regulation of nitrogen compound metabolic process
GO:60557; positive regulation of vitamin D biosynthetic process
GO:60559; positive regulation of calcidiol 1-monooxygenase activity
GO:1900222; negative regulation of amyloid-beta clearance
GO:33141; positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:9615; response to virus
GO:1819; positive regulation of cytokine production
GO:1934; positive regulation of protein phosphorylation
GO:2281; macrophage activation involved in immune response
GO:10634; positive regulation of epithelial cell migration
GO:10835; regulation of protein ADP-ribosylation
GO:30225; macrophage differentiation
GO:30857; negative regulation of epithelial cell differentiation
GO:31334; positive regulation of protein-containing complex assembly
GO:32722; positive regulation of chemokine production
GO:32747; positive regulation of interleukin-23 production
GO:34393; positive regulation of smooth muscle cell apoptotic process
GO:42307; positive regulation of protein import into nucleus
GO:45821; positive regulation of glycolytic process
GO:45892; negative regulation of transcription, DNA-templated
GO:48662; negative regulation of smooth muscle cell proliferation
GO:50766; positive regulation of phagocytosis
GO:50769; positive regulation of neurogenesis
GO:51712; positive regulation of killing of cells of other organism
GO:60333; interferon-gamma-mediated signaling pathway
GO:60550; positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
GO:60552; positive regulation of fructose 1,6-bisphosphate metabolic process
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:90312; positive regulation of protein deacetylation
GO:150076; neuroinflammatory response
GO:1902948; negative regulation of tau-protein kinase activity
GO:1904440; positive regulation of iron ion import across plasma membrane
GO:1904783; positive regulation of NMDA glutamate receptor activity
GO:1904798; positive regulation of core promoter binding
GO:2000309; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:98586; cellular response to virus
Cellular component: GO:5576; extracellular region
GO:5615; extracellular space
Function: GO:5515; protein binding
GO:5125; cytokine activity
GO:5133; interferon-gamma receptor binding
Hide GO terms

Homologs of IFNG in Model Organisms

Danio rerio
ifng1-2
Mus musculus
Ifng
Rattus norvegicus
Ifng

In other databases

LongevityMap
  • This gene is present as IFNG

External links

OMIM
147570
Ensembl
ENSG00000111537
Entrez Gene
3458
UniGene
856
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IFNG
GeneCards
IFNG