Cell Senescence Entries for IGFBP3

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Debacq-Chainiaux et al. (2008) Screening of senescence-associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblasts. Free Radic Biol Med 44(10)1817-32 (PubMed)

IGFBP3 Gene Information

HGNC symbol
IGFBP3 
Aliases
BP-53; IBP3 
Common name
insulin like growth factor binding protein 3 
Entrez Id
3486
Description
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

IGFBP3 Ontologies

Gene Ontology
Process: GO:1558; regulation of cell growth
GO:1649; osteoblast differentiation
GO:10906; regulation of glucose metabolic process
GO:40008; regulation of growth
GO:43410; positive regulation of MAPK cascade
GO:43568; positive regulation of insulin-like growth factor receptor signaling pathway
GO:44342; type B pancreatic cell proliferation
GO:6915; apoptotic process
GO:50790; regulation of catalytic activity
GO:9968; negative regulation of signal transduction
GO:43065; positive regulation of apoptotic process
GO:6468; protein phosphorylation
GO:14912; negative regulation of smooth muscle cell migration
GO:8285; negative regulation of cell population proliferation
GO:48662; negative regulation of smooth muscle cell proliferation
GO:43567; regulation of insulin-like growth factor receptor signaling pathway
GO:45663; positive regulation of myoblast differentiation
GO:1933; negative regulation of protein phosphorylation
Cellular component: GO:5576; extracellular region
GO:5615; extracellular space
GO:5634; nucleus
GO:5788; endoplasmic reticulum lumen
GO:16942; insulin-like growth factor binding protein complex
GO:42567; insulin-like growth factor ternary complex
Function: GO:5520; insulin-like growth factor binding
GO:19838; growth factor binding
GO:1968; fibronectin binding
GO:46872; metal ion binding
GO:5515; protein binding
GO:31994; insulin-like growth factor I binding
GO:31995; insulin-like growth factor II binding
GO:8160; protein tyrosine phosphatase activator activity
Hide GO terms

Homologs of IGFBP3 in Model Organisms

Danio rerio
igfbp3
Mus musculus
Igfbp3
Rattus norvegicus
Igfbp3

In other databases

GenAge human genes
  • This gene is present as IGFBP3
LongevityMap
  • This gene is present as IGFBP3
CellAge gene expression
  • This gene is present as IGFBP3

External links

OMIM
146732
Ensembl
ENSG00000146674
Entrez Gene
3486
UniGene
450230
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IGFBP3
GeneCards
IGFBP3