Cell Senescence Entries for IGFBP5

Cell Types
Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Kim et al. (2008) Induction of cellular senescence by insulin-like growth factor binding protein-5 through a p53-dependent mechanism. Mol Biol Cell 18(11)4543-52 (PubMed)

IGFBP5 Gene Information

HGNC symbol
IGFBP5 
Aliases
 
Common name
insulin like growth factor binding protein 5 
Entrez Id
3488
Description

IGFBP5 Ontologies

Gene Ontology
Process: GO:1904707; positive regulation of vascular associated smooth muscle cell proliferation
GO:17148; negative regulation of translation
GO:60416; response to growth hormone
GO:7165; signal transduction
GO:71320; cellular response to cAMP
GO:30336; negative regulation of cell migration
GO:43569; negative regulation of insulin-like growth factor receptor signaling pathway
GO:14912; negative regulation of smooth muscle cell migration
GO:1904754; positive regulation of vascular associated smooth muscle cell migration
GO:71407; cellular response to organic cyclic compound
GO:48662; negative regulation of smooth muscle cell proliferation
GO:43567; regulation of insulin-like growth factor receptor signaling pathway
GO:1558; regulation of cell growth
GO:1649; osteoblast differentiation
GO:7565; female pregnancy
GO:7568; aging
GO:31069; hair follicle morphogenesis
GO:35556; intracellular signal transduction
GO:40008; regulation of growth
GO:42593; glucose homeostasis
GO:43568; positive regulation of insulin-like growth factor receptor signaling pathway
GO:44342; type B pancreatic cell proliferation
GO:45668; negative regulation of osteoblast differentiation
GO:45926; negative regulation of growth
GO:48286; lung alveolus development
GO:51146; striated muscle cell differentiation
GO:51897; positive regulation of protein kinase B signaling
GO:60056; mammary gland involution
GO:1901862; negative regulation of muscle tissue development
GO:1904205; negative regulation of skeletal muscle hypertrophy
Cellular component: GO:5576; extracellular region
GO:5615; extracellular space
GO:5788; endoplasmic reticulum lumen
GO:16942; insulin-like growth factor binding protein complex
GO:42567; insulin-like growth factor ternary complex
Function: GO:5515; protein binding
GO:5520; insulin-like growth factor binding
GO:19838; growth factor binding
GO:1968; fibronectin binding
GO:31994; insulin-like growth factor I binding
GO:31995; insulin-like growth factor II binding
Hide GO terms

Homologs of IGFBP5 in Model Organisms

Danio rerio
igfbp5a
Mus musculus
Igfbp5
Rattus norvegicus
Igfbp5

In other databases

LongevityMap
  • This gene is present as IGFBP5
CellAge gene expression
  • This gene is present as IGFBP5

External links

OMIM
146734
Ensembl
ENSG00000115461
Entrez Gene
3488
UniGene
607212
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IGFBP5
GeneCards
IGFBP5