Cell Senescence Entries for IGFBP7

Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wajapeyee et al. (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132(3)363-74 (PubMed)
Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Zuo et al. (2012) IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells. J Cancer Res Clin Oncol 138(6)1045-55 (PubMed)

IGFBP7 Gene Information

HGNC symbol
IGFBP7 
Aliases
FSTL2; IGFBP-7; MAC25; PSF 
Common name
insulin like growth factor binding protein 7 
Entrez Id
3490
Description
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011].

IGFBP7 Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:1558; regulation of cell growth
GO:8285; negative regulation of cell population proliferation
GO:9966; regulation of signal transduction
GO:7566; embryo implantation
GO:9408; response to heat
GO:14070; response to organic cyclic compound
GO:32526; response to retinoic acid
GO:32870; cellular response to hormone stimulus
GO:50810; regulation of steroid biosynthetic process
GO:51414; response to cortisol
Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:5788; endoplasmic reticulum lumen
Function: GO:5520; insulin-like growth factor binding
GO:19838; growth factor binding
GO:5515; protein binding
GO:5201; extracellular matrix structural constituent
Hide GO terms

Homologs of IGFBP7 in Model Organisms

Danio rerio
igfbp7
Mus musculus
Igfbp7
Rattus norvegicus
Igfbp7

In other databases

CellAge gene expression
  • This gene is present as IGFBP7

External links

OMIM
602867
Ensembl
ENSG00000163453
Entrez Gene
3490
UniGene
691061
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IGFBP7
GeneCards
IGFBP7