Cell Senescence Entries for IL1A

Cell Types
Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Maier et al. (1990) Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer. Science 249(4976)1570-4 (PubMed)

IL1A Gene Information

HGNC symbol
IL1A 
Aliases
IL-1A; IL1; IL1-ALPHA; IL1F1 
Common name
interleukin 1 alpha 
Entrez Id
3552
Description
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008].

IL1A Ontologies

Gene Ontology
Process: GO:6955; immune response
GO:6954; inflammatory response
GO:51781; positive regulation of cell division
GO:71222; cellular response to lipopolysaccharide
GO:10628; positive regulation of gene expression
GO:19221; cytokine-mediated signaling pathway
GO:1660; fever generation
GO:32755; positive regulation of interleukin-6 production
GO:32760; positive regulation of tumor necrosis factor production
GO:45766; positive regulation of angiogenesis
GO:6915; apoptotic process
GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:8285; negative regulation of cell population proliferation
GO:1819; positive regulation of cytokine production
GO:34605; cellular response to heat
GO:45840; positive regulation of mitotic nuclear division
GO:10575; positive regulation of vascular endothelial growth factor production
GO:32743; positive regulation of interleukin-2 production
GO:1666; response to hypoxia
GO:2248; connective tissue replacement involved in inflammatory response wound healing
GO:2526; acute inflammatory response
GO:6883; cellular sodium ion homeostasis
GO:7283; spermatogenesis
GO:7507; heart development
GO:9408; response to heat
GO:10033; response to organic substance
GO:10193; response to ozone
GO:10243; response to organonitrogen compound
GO:10332; response to gamma radiation
GO:10893; positive regulation of steroid biosynthetic process
GO:14070; response to organic cyclic compound
GO:31424; keratinization
GO:32308; positive regulation of prostaglandin secretion
GO:32496; response to lipopolysaccharide
GO:32874; positive regulation of stress-activated MAPK cascade
GO:32956; regulation of actin cytoskeleton organization
GO:33092; positive regulation of immature T cell proliferation in thymus
GO:33591; response to L-ascorbic acid
GO:35234; ectopic germ cell programmed cell death
GO:42060; wound healing
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:45944; positive regulation of transcription by RNA polymerase II
GO:46330; positive regulation of JNK cascade
GO:46688; response to copper ion
GO:50714; positive regulation of protein secretion
GO:50999; regulation of nitric-oxide synthase activity
GO:51930; regulation of sensory perception of pain
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
GO:1902624; positive regulation of neutrophil migration
GO:1904445; negative regulation of establishment of Sertoli cell barrier
Cellular component: GO:5615; extracellular space
GO:5737; cytoplasm
GO:5576; extracellular region
GO:5829; cytosol
GO:5886; plasma membrane
GO:9986; cell surface
Function: GO:5515; protein binding
GO:5125; cytokine activity
GO:5149; interleukin-1 receptor binding
GO:5507; copper ion binding
Hide GO terms

Homologs of IL1A in Model Organisms

Mus musculus
Il1a
Rattus norvegicus
Il1a

In other databases

LongevityMap
  • This gene is present as IL1A

External links

OMIM
147760
Ensembl
ENSG00000115008
Entrez Gene
3552
UniGene
1722
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IL1A
GeneCards
IL1A