Cell Senescence Entries for IL1RN

Cell Types
HUVEC
Cell Lines
Primary cell
Cancer Cell?
No
Method
Mutation
Type of senescence
Replicative
Senescence Effect
Unclear
Primary Reference
Dewberry et al. (2003) Interleukin-1 receptor antagonist (IL-1RN) genotype modulates the replicative capacity of human endothelial cells. Circ Res 92(12)1285-7 (PubMed)

IL1RN Gene Information

HGNC symbol
IL1RN 
Aliases
ICIL-1RA; IL-1RN; IL1F3; IL1RA; IRAP; MGC10430 
Common name
interleukin 1 receptor antagonist 
Entrez Id
3557
Description
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020].

IL1RN Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:6955; immune response
GO:6954; inflammatory response
GO:2000660; negative regulation of interleukin-1-mediated signaling pathway
GO:34115; negative regulation of heterotypic cell-cell adhesion
GO:51384; response to glucocorticoid
GO:2437; inflammatory response to antigenic stimulus
GO:1960; negative regulation of cytokine-mediated signaling pathway
GO:6953; acute-phase response
GO:6629; lipid metabolic process
GO:30073; insulin secretion
Cellular component: GO:5615; extracellular space
GO:5737; cytoplasm
GO:5576; extracellular region
GO:5886; plasma membrane
GO:70062; extracellular exosome
GO:31982; vesicle
Function: GO:5515; protein binding
GO:5125; cytokine activity
GO:5149; interleukin-1 receptor binding
GO:5152; interleukin-1 receptor antagonist activity
GO:5150; interleukin-1, type I receptor binding
GO:5151; interleukin-1, type II receptor binding
GO:45352; interleukin-1 type I receptor antagonist activity
GO:45353; interleukin-1 type II receptor antagonist activity
Hide GO terms

Homologs of IL1RN in Model Organisms

Mus musculus
Il1rn
Rattus norvegicus
Il1rn

In other databases

LongevityMap
  • This gene is present as IL1RN

External links

OMIM
147679
Ensembl
ENSG00000136689
Entrez Gene
3557
UniGene
81134
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IL1RN
GeneCards
IL1RN